Synoviocyte Derived-Extracellular Matrix Enhances Human Articular Chondrocyte Proliferation and Maintains Re-Differentiation Capacity at Both Low and Atmospheric Oxygen Tensions

Current tissue engineering methods are insufficient for total joint resurfacing, and chondrocytes undergo de-differentiation when expanded on tissue culture plastic. De-differentiated chondrocytes show poor re-differentiation in culture, giving reduced glycosaminoglycan (GAG) and collagen matrix acc...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0129961-e0129961
Hauptverfasser:	Kean, Thomas J, Dennis, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Aggrecan Aggregates Animals Atmospheric oxygen Cartilage Cartilage, Articular - cytology Cell culture Cell Culture Techniques Cell Differentiation - drug effects Cell Self Renewal Cells, Cultured Chondrocytes Chondrocytes - cytology Chondrocytes - metabolism Chondrogenesis Collagen Collagen (type I) Collagen (type II) Collagenase 3 Detergents Differentiation Expansion Extracellular matrix Extracellular Matrix - metabolism Gene Expression Gene Expression Profiling Glycosaminoglycans - metabolism Glycosaminoglycans - pharmacology Growth rate Human performance Humans Hydroxyproline - metabolism Mucopolysaccharides Oxygen Oxygen - metabolism Oxygen tension Phenotypes Plastics Resurfacing Sox9 protein Surfacing Swine Synovial Membrane - cytology Tension Tissue culture Tissue engineering
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