Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases

The infectious agents of the transmissible spongiform encephalopathies are composed of amyloidogenic prion protein, PrPSc. Real-time quaking-induced conversion can amplify very small amounts of PrPSc seeds in tissues/body fluids of patients or animals. Using this in vitro PrP-amyloid amplification a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0126930-e0126930
Hauptverfasser:	Takatsuki, Hanae, Satoh, Katsuya, Sano, Kazunori, Fuse, Takayuki, Nakagaki, Takehiro, Mori, Tsuyoshi, Ishibashi, Daisuke, Mihara, Ban, Takao, Masaki, Iwasaki, Yasushi, Yoshida, Mari, Atarashi, Ryuichiro, Nishida, Noriyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amplification Amyloid Amyloid - metabolism Amyloidogenesis Assaying Autoclaving Autopsies Autopsy Bioassays Body fluids Brain Brain - metabolism Brain - pathology Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - diagnosis Creutzfeldt-Jakob Syndrome - metabolism Dilution Female Hospitals Humans Immunology Male Middle Aged Neurology Neuropathology Patients Prion Diseases - diagnosis Prion Diseases - genetics Prion Diseases - metabolism Prion protein Prions - metabolism Protein seeding Proteins PrPSc Proteins - metabolism Quantitation Rodents Seeds Studies Transgenic animals Transmissible spongiform encephalopathy University graduates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!