Evaluation of the Valve Academic Research Consortium-2 Criteria for Myocardial Infarction in Transcatheter Aortic Valve Implantation: A Prospective Observational Study
To evaluate the relevance of the individual components of the Valve Academic Research Consortium (VARC)-2 criteria for periprocedural myocardial infarction (MI) in transcatheter aortic valve implantation (TAVI). The association between biomarkers and adverse procedural outcome has been established....
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-06, Vol.10 (6), p.e0130423 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | e0130423 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Nilsson, Lennart Appel, Carl-Fredrik Hultkvist, Henrik Vánky, Farkas |
| description | To evaluate the relevance of the individual components of the Valve Academic Research Consortium (VARC)-2 criteria for periprocedural myocardial infarction (MI) in transcatheter aortic valve implantation (TAVI). The association between biomarkers and adverse procedural outcome has been established. However, the additive prognostic importance of signs and symptoms are more uncertain.
A total of 125 consecutive TAVI patients were prospectively included in this study. Biomarkers for MI were analyzed and signs and symptoms according to VARC-2 criteria were collected from clinical records.
The criteria of elevated biomarkers and of signs or symptoms were found in 27 (22%) and 32 (26%) of the patients, respectively. According to VARC-2 definition, 12 (10%) had MI. VARC-2 definition of MI, Troponin T (TnT) > 600 ng/L, and presence of signs or symptoms correlated with 6 months mortality, prolonged ICU stay, elevation of N-terminal prohormone brain natriuretic peptide, and renal impairment. No signs or symptoms were found in 7 (44%) of the patients who fulfilled the criterion of elevated TnT > 600 ng/L. In the group with positive TnT criterion, there were no significant differences between those with and without signs or symptoms in respect to levels of TnT (1014 [585-1720] ng/L versus 704 [515-905] ng/L, p = 0.17) or creatine kinase-MB (36 [25-52] μg/L versus 29 [25-39] μg/L, p = 0.32). In the multivariate Cox regression analysis, TnT > 600 ng/L was the only significant independent variable associated with 6-months postprocedural mortality.
Myocardial injury in TAVI, measured with biomarkers, correlates well with adverse procedural outcome. In this study it is also the strongest predictor for early postprocedural mortality. The additional requirement of signs or symptoms for the diagnosis of MI results in omission of a considerable number of clinically significant MI. |
| doi_str_mv | 10.1371/journal.pone.0130423 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1687821886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A417656761</galeid><doaj_id>oai_doaj_org_article_6896bfd06ddf4b0cb6ec75fb8e026125</doaj_id><sourcerecordid>A417656761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c730t-b3d17181abfe8275c111b9f6b3699dcd56a4dd0c820dccf44e123339fb40a973</originalsourceid><addsrcrecordid>eNqNk9uO0zAQhiMEYpeFN0BgCQnBRYsPiZNwgVSVBSotKtqtems5PrReuXGxk0KfiNfEabOrBu0FV4k83_97ZjyTJC8RHCOSow-3rvU1t-Otq9UYIgJTTB4l56gkeEQxJI9P_s-SZyHcQpiRgtKnyRmmkJZlVpwnfy533La8Ma4GToNmrcCS250CE8Gl2hgBrlVQ3Is1mLo6ON-YdjPCYOpNo7zhQDsPvu-d4F4absGs1hE-2JkaLDyvg-DRNcJg0qlF7z_bbC2vm8PNH8EE_PAubFVUxti8CsrvDqFoedO0cv88eaK5DepF_71IFl8uF9Nvo6v519l0cjUSOYHNqCIS5ahAvNKqwHkmEEJVqWlFYr1SyIzyVEooCgylEDpNFcKEkFJXKeRlTi6S10fbrXWB9S0ODNEiLzAqChqJ2ZGQjt-yrTcb7vfMccMOB86vGO_KtIrRoqSVlpBKqdMKiooqkWe6KhTEFOEseo2OXuGX2rbVwO2zWU4Obta0DGGICYr8pz67ttooKVTdeG4HsmGkNmu2cjuWppRmWZf8u97Au5-tCg3bmCCUjS-hXHuosySwzDIY0Tf_oA93o6dWPBZsau3ivaIzZZMU5TSjOe3yHj9A8X7C4vxqE88HgvcDQWQa9btZ8TYENru5_n92vhyyb0_YteK2WQdn227SwhBMj6CIYxm80vdNRpB163fXDdatH-vXL8penT7Qvehu38hf6eotyA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1687821886</pqid></control><display><type>article</type><title>Evaluation of the Valve Academic Research Consortium-2 Criteria for Myocardial Infarction in Transcatheter Aortic Valve Implantation: A Prospective Observational Study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Nilsson, Lennart ; Appel, Carl-Fredrik ; Hultkvist, Henrik ; Vánky, Farkas</creator><creatorcontrib>Nilsson, Lennart ; Appel, Carl-Fredrik ; Hultkvist, Henrik ; Vánky, Farkas</creatorcontrib><description>To evaluate the relevance of the individual components of the Valve Academic Research Consortium (VARC)-2 criteria for periprocedural myocardial infarction (MI) in transcatheter aortic valve implantation (TAVI). The association between biomarkers and adverse procedural outcome has been established. However, the additive prognostic importance of signs and symptoms are more uncertain.
A total of 125 consecutive TAVI patients were prospectively included in this study. Biomarkers for MI were analyzed and signs and symptoms according to VARC-2 criteria were collected from clinical records.
The criteria of elevated biomarkers and of signs or symptoms were found in 27 (22%) and 32 (26%) of the patients, respectively. According to VARC-2 definition, 12 (10%) had MI. VARC-2 definition of MI, Troponin T (TnT) > 600 ng/L, and presence of signs or symptoms correlated with 6 months mortality, prolonged ICU stay, elevation of N-terminal prohormone brain natriuretic peptide, and renal impairment. No signs or symptoms were found in 7 (44%) of the patients who fulfilled the criterion of elevated TnT > 600 ng/L. In the group with positive TnT criterion, there were no significant differences between those with and without signs or symptoms in respect to levels of TnT (1014 [585-1720] ng/L versus 704 [515-905] ng/L, p = 0.17) or creatine kinase-MB (36 [25-52] μg/L versus 29 [25-39] μg/L, p = 0.32). In the multivariate Cox regression analysis, TnT > 600 ng/L was the only significant independent variable associated with 6-months postprocedural mortality.
Myocardial injury in TAVI, measured with biomarkers, correlates well with adverse procedural outcome. In this study it is also the strongest predictor for early postprocedural mortality. The additional requirement of signs or symptoms for the diagnosis of MI results in omission of a considerable number of clinically significant MI.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0130423</identifier><identifier>PMID: 26069958</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged, 80 and over ; Analysis ; Aorta ; Aortic valve ; Biomarkers ; Biomarkers - blood ; Brain ; Brain natriuretic peptide ; Calcium-binding protein ; Cardiology ; Clinical outcomes ; Consortia ; Correlation analysis ; Creatine ; Creatine kinase ; Criteria ; Electrocardiography ; Female ; Health aspects ; Health sciences ; Heart attack ; Heart attacks ; Heart valve diseases ; Hospitalization ; Hospitals ; Humans ; Implantation ; Independent variables ; Infarction ; Male ; Mortality ; Myocardial infarction ; Myocardial Infarction - blood ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - mortality ; Myocardial Infarction - surgery ; Natriuretic peptides ; Observational studies ; Patients ; Proportional Hazards Models ; Prospective Studies ; Regression analysis ; Renal function ; Risk Factors ; Signs and symptoms ; Transcatheter Aortic Valve Replacement ; Treatment Outcome ; Troponin ; Troponin T ; Ultrasonography ; Vascular surgery</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0130423</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Nilsson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Nilsson et al 2015 Nilsson et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c730t-b3d17181abfe8275c111b9f6b3699dcd56a4dd0c820dccf44e123339fb40a973</citedby><cites>FETCH-LOGICAL-c730t-b3d17181abfe8275c111b9f6b3699dcd56a4dd0c820dccf44e123339fb40a973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466556/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466556/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26069958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120231$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nilsson, Lennart</creatorcontrib><creatorcontrib>Appel, Carl-Fredrik</creatorcontrib><creatorcontrib>Hultkvist, Henrik</creatorcontrib><creatorcontrib>Vánky, Farkas</creatorcontrib><title>Evaluation of the Valve Academic Research Consortium-2 Criteria for Myocardial Infarction in Transcatheter Aortic Valve Implantation: A Prospective Observational Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To evaluate the relevance of the individual components of the Valve Academic Research Consortium (VARC)-2 criteria for periprocedural myocardial infarction (MI) in transcatheter aortic valve implantation (TAVI). The association between biomarkers and adverse procedural outcome has been established. However, the additive prognostic importance of signs and symptoms are more uncertain.
A total of 125 consecutive TAVI patients were prospectively included in this study. Biomarkers for MI were analyzed and signs and symptoms according to VARC-2 criteria were collected from clinical records.
The criteria of elevated biomarkers and of signs or symptoms were found in 27 (22%) and 32 (26%) of the patients, respectively. According to VARC-2 definition, 12 (10%) had MI. VARC-2 definition of MI, Troponin T (TnT) > 600 ng/L, and presence of signs or symptoms correlated with 6 months mortality, prolonged ICU stay, elevation of N-terminal prohormone brain natriuretic peptide, and renal impairment. No signs or symptoms were found in 7 (44%) of the patients who fulfilled the criterion of elevated TnT > 600 ng/L. In the group with positive TnT criterion, there were no significant differences between those with and without signs or symptoms in respect to levels of TnT (1014 [585-1720] ng/L versus 704 [515-905] ng/L, p = 0.17) or creatine kinase-MB (36 [25-52] μg/L versus 29 [25-39] μg/L, p = 0.32). In the multivariate Cox regression analysis, TnT > 600 ng/L was the only significant independent variable associated with 6-months postprocedural mortality.
Myocardial injury in TAVI, measured with biomarkers, correlates well with adverse procedural outcome. In this study it is also the strongest predictor for early postprocedural mortality. The additional requirement of signs or symptoms for the diagnosis of MI results in omission of a considerable number of clinically significant MI.</description><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Aorta</subject><subject>Aortic valve</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Brain</subject><subject>Brain natriuretic peptide</subject><subject>Calcium-binding protein</subject><subject>Cardiology</subject><subject>Clinical outcomes</subject><subject>Consortia</subject><subject>Correlation analysis</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Criteria</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>Heart attack</subject><subject>Heart attacks</subject><subject>Heart valve diseases</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Implantation</subject><subject>Independent variables</subject><subject>Infarction</subject><subject>Male</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - surgery</subject><subject>Natriuretic peptides</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Renal function</subject><subject>Risk Factors</subject><subject>Signs and symptoms</subject><subject>Transcatheter Aortic Valve Replacement</subject><subject>Treatment Outcome</subject><subject>Troponin</subject><subject>Troponin T</subject><subject>Ultrasonography</subject><subject>Vascular surgery</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9uO0zAQhiMEYpeFN0BgCQnBRYsPiZNwgVSVBSotKtqtems5PrReuXGxk0KfiNfEabOrBu0FV4k83_97ZjyTJC8RHCOSow-3rvU1t-Otq9UYIgJTTB4l56gkeEQxJI9P_s-SZyHcQpiRgtKnyRmmkJZlVpwnfy533La8Ma4GToNmrcCS250CE8Gl2hgBrlVQ3Is1mLo6ON-YdjPCYOpNo7zhQDsPvu-d4F4absGs1hE-2JkaLDyvg-DRNcJg0qlF7z_bbC2vm8PNH8EE_PAubFVUxti8CsrvDqFoedO0cv88eaK5DepF_71IFl8uF9Nvo6v519l0cjUSOYHNqCIS5ahAvNKqwHkmEEJVqWlFYr1SyIzyVEooCgylEDpNFcKEkFJXKeRlTi6S10fbrXWB9S0ODNEiLzAqChqJ2ZGQjt-yrTcb7vfMccMOB86vGO_KtIrRoqSVlpBKqdMKiooqkWe6KhTEFOEseo2OXuGX2rbVwO2zWU4Obta0DGGICYr8pz67ttooKVTdeG4HsmGkNmu2cjuWppRmWZf8u97Au5-tCg3bmCCUjS-hXHuosySwzDIY0Tf_oA93o6dWPBZsau3ivaIzZZMU5TSjOe3yHj9A8X7C4vxqE88HgvcDQWQa9btZ8TYENru5_n92vhyyb0_YteK2WQdn227SwhBMj6CIYxm80vdNRpB163fXDdatH-vXL8penT7Qvehu38hf6eotyA</recordid><startdate>20150612</startdate><enddate>20150612</enddate><creator>Nilsson, Lennart</creator><creator>Appel, Carl-Fredrik</creator><creator>Hultkvist, Henrik</creator><creator>Vánky, Farkas</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ABXSW</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DG8</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20150612</creationdate><title>Evaluation of the Valve Academic Research Consortium-2 Criteria for Myocardial Infarction in Transcatheter Aortic Valve Implantation: A Prospective Observational Study</title><author>Nilsson, Lennart ; Appel, Carl-Fredrik ; Hultkvist, Henrik ; Vánky, Farkas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c730t-b3d17181abfe8275c111b9f6b3699dcd56a4dd0c820dccf44e123339fb40a973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Aorta</topic><topic>Aortic valve</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Brain</topic><topic>Brain natriuretic peptide</topic><topic>Calcium-binding protein</topic><topic>Cardiology</topic><topic>Clinical outcomes</topic><topic>Consortia</topic><topic>Correlation analysis</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Criteria</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health sciences</topic><topic>Heart attack</topic><topic>Heart attacks</topic><topic>Heart valve diseases</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Implantation</topic><topic>Independent variables</topic><topic>Infarction</topic><topic>Male</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - mortality</topic><topic>Myocardial Infarction - surgery</topic><topic>Natriuretic peptides</topic><topic>Observational studies</topic><topic>Patients</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Renal function</topic><topic>Risk Factors</topic><topic>Signs and symptoms</topic><topic>Transcatheter Aortic Valve Replacement</topic><topic>Treatment Outcome</topic><topic>Troponin</topic><topic>Troponin T</topic><topic>Ultrasonography</topic><topic>Vascular surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nilsson, Lennart</creatorcontrib><creatorcontrib>Appel, Carl-Fredrik</creatorcontrib><creatorcontrib>Hultkvist, Henrik</creatorcontrib><creatorcontrib>Vánky, Farkas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Linköpings universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Linköpings universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nilsson, Lennart</au><au>Appel, Carl-Fredrik</au><au>Hultkvist, Henrik</au><au>Vánky, Farkas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Valve Academic Research Consortium-2 Criteria for Myocardial Infarction in Transcatheter Aortic Valve Implantation: A Prospective Observational Study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-12</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0130423</spage><pages>e0130423-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate the relevance of the individual components of the Valve Academic Research Consortium (VARC)-2 criteria for periprocedural myocardial infarction (MI) in transcatheter aortic valve implantation (TAVI). The association between biomarkers and adverse procedural outcome has been established. However, the additive prognostic importance of signs and symptoms are more uncertain.
A total of 125 consecutive TAVI patients were prospectively included in this study. Biomarkers for MI were analyzed and signs and symptoms according to VARC-2 criteria were collected from clinical records.
The criteria of elevated biomarkers and of signs or symptoms were found in 27 (22%) and 32 (26%) of the patients, respectively. According to VARC-2 definition, 12 (10%) had MI. VARC-2 definition of MI, Troponin T (TnT) > 600 ng/L, and presence of signs or symptoms correlated with 6 months mortality, prolonged ICU stay, elevation of N-terminal prohormone brain natriuretic peptide, and renal impairment. No signs or symptoms were found in 7 (44%) of the patients who fulfilled the criterion of elevated TnT > 600 ng/L. In the group with positive TnT criterion, there were no significant differences between those with and without signs or symptoms in respect to levels of TnT (1014 [585-1720] ng/L versus 704 [515-905] ng/L, p = 0.17) or creatine kinase-MB (36 [25-52] μg/L versus 29 [25-39] μg/L, p = 0.32). In the multivariate Cox regression analysis, TnT > 600 ng/L was the only significant independent variable associated with 6-months postprocedural mortality.
Myocardial injury in TAVI, measured with biomarkers, correlates well with adverse procedural outcome. In this study it is also the strongest predictor for early postprocedural mortality. The additional requirement of signs or symptoms for the diagnosis of MI results in omission of a considerable number of clinically significant MI.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26069958</pmid><doi>10.1371/journal.pone.0130423</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-06, Vol.10 (6), p.e0130423 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1687821886 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Aged, 80 and over Analysis Aorta Aortic valve Biomarkers Biomarkers - blood Brain Brain natriuretic peptide Calcium-binding protein Cardiology Clinical outcomes Consortia Correlation analysis Creatine Creatine kinase Criteria Electrocardiography Female Health aspects Health sciences Heart attack Heart attacks Heart valve diseases Hospitalization Hospitals Humans Implantation Independent variables Infarction Male Mortality Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - diagnostic imaging Myocardial Infarction - mortality Myocardial Infarction - surgery Natriuretic peptides Observational studies Patients Proportional Hazards Models Prospective Studies Regression analysis Renal function Risk Factors Signs and symptoms Transcatheter Aortic Valve Replacement Treatment Outcome Troponin Troponin T Ultrasonography Vascular surgery |
| title | Evaluation of the Valve Academic Research Consortium-2 Criteria for Myocardial Infarction in Transcatheter Aortic Valve Implantation: A Prospective Observational Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T00%3A48%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20the%20Valve%20Academic%20Research%20Consortium-2%20Criteria%20for%20Myocardial%20Infarction%20in%20Transcatheter%20Aortic%20Valve%20Implantation:%20A%20Prospective%20Observational%20Study&rft.jtitle=PloS%20one&rft.au=Nilsson,%20Lennart&rft.date=2015-06-12&rft.volume=10&rft.issue=6&rft.spage=e0130423&rft.pages=e0130423-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0130423&rft_dat=%3Cgale_plos_%3EA417656761%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1687821886&rft_id=info:pmid/26069958&rft_galeid=A417656761&rft_doaj_id=oai_doaj_org_article_6896bfd06ddf4b0cb6ec75fb8e026125&rfr_iscdi=true |