Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in Patients with Unresectable Colorectal Cancer
Skeletal muscle depletion (sarcopenia) is closely associated with limited physical ability and high mortality. This study evaluated the prognostic significance of skeletal muscle status before and after chemotherapy in patients with unresectable colorectal cancer (CRC). We conducted a retrospective...
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| creator | Miyamoto, Yuji Baba, Yoshifumi Sakamoto, Yasuo Ohuchi, Mayuko Tokunaga, Ryuma Kurashige, Junji Hiyoshi, Yukiharu Iwagami, Shiro Yoshida, Naoya Watanabe, Masayuki Baba, Hideo |
| description | Skeletal muscle depletion (sarcopenia) is closely associated with limited physical ability and high mortality. This study evaluated the prognostic significance of skeletal muscle status before and after chemotherapy in patients with unresectable colorectal cancer (CRC).
We conducted a retrospective analysis of 215 consecutive patients with unresectable CRC who underwent systemic chemotherapy. Skeletal muscle cross-sectional area was measured by computed tomography. We evaluated the prognostic value of skeletal muscle mass before chemotherapy and the rate of skeletal muscle change in cross-sectional area after chemotherapy.
One-hundred-eighty-two patients met our inclusion criteria. There were no significant differences in progression-free survival (PFS) or overall survival (OS) associated with skeletal muscle mass before chemotherapy. However, 22 patients with skeletal muscle loss (>5%) after chemotherapy showed significantly shorter PFS and OS compared with those without skeletal muscle loss (PFS, log-rank p = 0.029; OS, log-rank p = 0.009). Multivariate Cox regression analysis revealed that skeletal muscle loss after chemotherapy (hazard ratio, 2.079; 95% confidence interval, 1.194-3.619; p = 0.010) was independently associated with OS.
Skeletal muscle loss after chemotherapy was an independent, negative prognostic factor in unresectable CRC. |
| doi_str_mv | 10.1371/journal.pone.0129742 |
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We conducted a retrospective analysis of 215 consecutive patients with unresectable CRC who underwent systemic chemotherapy. Skeletal muscle cross-sectional area was measured by computed tomography. We evaluated the prognostic value of skeletal muscle mass before chemotherapy and the rate of skeletal muscle change in cross-sectional area after chemotherapy.
One-hundred-eighty-two patients met our inclusion criteria. There were no significant differences in progression-free survival (PFS) or overall survival (OS) associated with skeletal muscle mass before chemotherapy. However, 22 patients with skeletal muscle loss (>5%) after chemotherapy showed significantly shorter PFS and OS compared with those without skeletal muscle loss (PFS, log-rank p = 0.029; OS, log-rank p = 0.009). Multivariate Cox regression analysis revealed that skeletal muscle loss after chemotherapy (hazard ratio, 2.079; 95% confidence interval, 1.194-3.619; p = 0.010) was independently associated with OS.
Skeletal muscle loss after chemotherapy was an independent, negative prognostic factor in unresectable CRC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0129742</identifier><identifier>PMID: 26069972</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Body composition ; Cancer ; Cancer patients ; Cancer therapies ; Care and treatment ; Chemotherapy ; Clinical outcomes ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - complications ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - drug therapy ; Computed tomography ; Confidence intervals ; Cross sections ; Female ; Health aspects ; Hospitals ; Humans ; Hypothesis testing ; Liver cancer ; Lung cancer ; Male ; Medical imaging ; Medical prognosis ; Melanoma ; Metastasis ; Mortality ; Muscles ; Musculoskeletal system ; Patients ; Prognosis ; Regression analysis ; Sarcopenia ; Sarcopenia - complications ; Sarcopenia - epidemiology ; Skeletal muscle ; Statistical analysis ; Surgery ; Surgical outcomes ; Survival ; Survival analysis ; Tumors</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0129742-e0129742</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Miyamoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Miyamoto et al 2015 Miyamoto et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-20e48c765cbbae2b1c00b72ff364951d7b46c9535de04437dfcd786e1cee95433</citedby><cites>FETCH-LOGICAL-c692t-20e48c765cbbae2b1c00b72ff364951d7b46c9535de04437dfcd786e1cee95433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466562/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466562/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26069972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Taketomi, Akinobu</contributor><creatorcontrib>Miyamoto, Yuji</creatorcontrib><creatorcontrib>Baba, Yoshifumi</creatorcontrib><creatorcontrib>Sakamoto, Yasuo</creatorcontrib><creatorcontrib>Ohuchi, Mayuko</creatorcontrib><creatorcontrib>Tokunaga, Ryuma</creatorcontrib><creatorcontrib>Kurashige, Junji</creatorcontrib><creatorcontrib>Hiyoshi, Yukiharu</creatorcontrib><creatorcontrib>Iwagami, Shiro</creatorcontrib><creatorcontrib>Yoshida, Naoya</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><creatorcontrib>Baba, Hideo</creatorcontrib><title>Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in Patients with Unresectable Colorectal Cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Skeletal muscle depletion (sarcopenia) is closely associated with limited physical ability and high mortality. This study evaluated the prognostic significance of skeletal muscle status before and after chemotherapy in patients with unresectable colorectal cancer (CRC).
We conducted a retrospective analysis of 215 consecutive patients with unresectable CRC who underwent systemic chemotherapy. Skeletal muscle cross-sectional area was measured by computed tomography. We evaluated the prognostic value of skeletal muscle mass before chemotherapy and the rate of skeletal muscle change in cross-sectional area after chemotherapy.
One-hundred-eighty-two patients met our inclusion criteria. There were no significant differences in progression-free survival (PFS) or overall survival (OS) associated with skeletal muscle mass before chemotherapy. However, 22 patients with skeletal muscle loss (>5%) after chemotherapy showed significantly shorter PFS and OS compared with those without skeletal muscle loss (PFS, log-rank p = 0.029; OS, log-rank p = 0.009). Multivariate Cox regression analysis revealed that skeletal muscle loss after chemotherapy (hazard ratio, 2.079; 95% confidence interval, 1.194-3.619; p = 0.010) was independently associated with OS.
Skeletal muscle loss after chemotherapy was an independent, negative prognostic factor in unresectable CRC.</description><subject>Aged</subject><subject>Body composition</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - complications</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Computed tomography</subject><subject>Confidence intervals</subject><subject>Cross sections</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypothesis testing</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Sarcopenia</subject><subject>Sarcopenia - complications</subject><subject>Sarcopenia - epidemiology</subject><subject>Skeletal muscle</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAYhSMEYmPwDxBYQkJw0eKvOPXNpKnio1JhiDJuLcd506Y4cbGdQf897ppNLdoF8oVj5znH9rHfLHtO8Jiwgrxbu9532o43roMxJlQWnD7ITolkdCQoZg8Pvk-yJyGsMc7ZRIjH2QkVWEhZ0NMsfIGljs01oFm70SYiV6PFT7AQtUWf-2AsoLkLAek6gkeLbYjQNgZNV9C6uAKvN1vUdOhrMoEuBvS7iSt01XkIYKIuk3zqrPO7gUVT3RnwT7NHtbYBng39WXb14f336afR_PLjbHoxHxkhaRxRDHxiCpGbstRAS2IwLgta10xwmZOqKLkwMmd5BZhzVlS1qYqJAGIAZM4ZO8te7n031gU15BUUEZNiQklKIhGzPVE5vVYb37Tab5XTjbqZcH6ptI9NCkHVIFPTYHievGUuqaGGVTivmK5KqJPX-bBaX7ZQmZSG1_bI9PhP16zU0l0rzoXIBU0GbwYD7371EKJqm2DAWt2B62_2LRnBTO7QV_-g959uoJY6HaDpapfWNTtTdcFJClYUYpKo8T1UatXuotPjqps0fyR4eyRITIQ_can7ENRs8e3_2csfx-zrA3YF2sZVcLaPjevCMcj3oPHpZXqo70ImWO1q4zYNtasNNdRGkr04vKA70W0xsL9QoQs6</recordid><startdate>20150612</startdate><enddate>20150612</enddate><creator>Miyamoto, Yuji</creator><creator>Baba, Yoshifumi</creator><creator>Sakamoto, Yasuo</creator><creator>Ohuchi, Mayuko</creator><creator>Tokunaga, Ryuma</creator><creator>Kurashige, Junji</creator><creator>Hiyoshi, Yukiharu</creator><creator>Iwagami, Shiro</creator><creator>Yoshida, Naoya</creator><creator>Watanabe, Masayuki</creator><creator>Baba, Hideo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150612</creationdate><title>Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in Patients with Unresectable Colorectal Cancer</title><author>Miyamoto, Yuji ; Baba, Yoshifumi ; Sakamoto, Yasuo ; Ohuchi, Mayuko ; Tokunaga, Ryuma ; Kurashige, Junji ; Hiyoshi, Yukiharu ; Iwagami, Shiro ; Yoshida, Naoya ; Watanabe, Masayuki ; Baba, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-20e48c765cbbae2b1c00b72ff364951d7b46c9535de04437dfcd786e1cee95433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Body composition</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - complications</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Computed tomography</topic><topic>Confidence intervals</topic><topic>Cross sections</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypothesis testing</topic><topic>Liver cancer</topic><topic>Lung cancer</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>Melanoma</topic><topic>Metastasis</topic><topic>Mortality</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Sarcopenia</topic><topic>Sarcopenia - complications</topic><topic>Sarcopenia - epidemiology</topic><topic>Skeletal muscle</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyamoto, Yuji</creatorcontrib><creatorcontrib>Baba, Yoshifumi</creatorcontrib><creatorcontrib>Sakamoto, Yasuo</creatorcontrib><creatorcontrib>Ohuchi, Mayuko</creatorcontrib><creatorcontrib>Tokunaga, Ryuma</creatorcontrib><creatorcontrib>Kurashige, Junji</creatorcontrib><creatorcontrib>Hiyoshi, Yukiharu</creatorcontrib><creatorcontrib>Iwagami, Shiro</creatorcontrib><creatorcontrib>Yoshida, Naoya</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><creatorcontrib>Baba, Hideo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyamoto, Yuji</au><au>Baba, Yoshifumi</au><au>Sakamoto, Yasuo</au><au>Ohuchi, Mayuko</au><au>Tokunaga, Ryuma</au><au>Kurashige, Junji</au><au>Hiyoshi, Yukiharu</au><au>Iwagami, Shiro</au><au>Yoshida, Naoya</au><au>Watanabe, Masayuki</au><au>Baba, Hideo</au><au>Taketomi, Akinobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in Patients with Unresectable Colorectal Cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-12</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0129742</spage><epage>e0129742</epage><pages>e0129742-e0129742</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Skeletal muscle depletion (sarcopenia) is closely associated with limited physical ability and high mortality. This study evaluated the prognostic significance of skeletal muscle status before and after chemotherapy in patients with unresectable colorectal cancer (CRC).
We conducted a retrospective analysis of 215 consecutive patients with unresectable CRC who underwent systemic chemotherapy. Skeletal muscle cross-sectional area was measured by computed tomography. We evaluated the prognostic value of skeletal muscle mass before chemotherapy and the rate of skeletal muscle change in cross-sectional area after chemotherapy.
One-hundred-eighty-two patients met our inclusion criteria. There were no significant differences in progression-free survival (PFS) or overall survival (OS) associated with skeletal muscle mass before chemotherapy. However, 22 patients with skeletal muscle loss (>5%) after chemotherapy showed significantly shorter PFS and OS compared with those without skeletal muscle loss (PFS, log-rank p = 0.029; OS, log-rank p = 0.009). Multivariate Cox regression analysis revealed that skeletal muscle loss after chemotherapy (hazard ratio, 2.079; 95% confidence interval, 1.194-3.619; p = 0.010) was independently associated with OS.
Skeletal muscle loss after chemotherapy was an independent, negative prognostic factor in unresectable CRC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26069972</pmid><doi>10.1371/journal.pone.0129742</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Body composition Cancer Cancer patients Cancer therapies Care and treatment Chemotherapy Clinical outcomes Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - complications Colorectal Neoplasms - diagnosis Colorectal Neoplasms - drug therapy Computed tomography Confidence intervals Cross sections Female Health aspects Hospitals Humans Hypothesis testing Liver cancer Lung cancer Male Medical imaging Medical prognosis Melanoma Metastasis Mortality Muscles Musculoskeletal system Patients Prognosis Regression analysis Sarcopenia Sarcopenia - complications Sarcopenia - epidemiology Skeletal muscle Statistical analysis Surgery Surgical outcomes Survival Survival analysis Tumors |
| title | Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in Patients with Unresectable Colorectal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T03%3A38%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Negative%20Impact%20of%20Skeletal%20Muscle%20Loss%20after%20Systemic%20Chemotherapy%20in%20Patients%20with%20Unresectable%20Colorectal%20Cancer&rft.jtitle=PloS%20one&rft.au=Miyamoto,%20Yuji&rft.date=2015-06-12&rft.volume=10&rft.issue=6&rft.spage=e0129742&rft.epage=e0129742&rft.pages=e0129742-e0129742&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0129742&rft_dat=%3Cgale_plos_%3EA417656768%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1687821866&rft_id=info:pmid/26069972&rft_galeid=A417656768&rft_doaj_id=oai_doaj_org_article_fe9e9eaec455439592c2c3d05d3adbef&rfr_iscdi=true |