The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma
This study aimed to evaluate the dynamic computed tomographic (CT) appearance of focal radiation injury to cirrhotic liver tissue around the tumor following stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC). Seventy-seven patients with 92 HCCs were observed for >6 mont...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-06, Vol.10 (6), p.e0125231-e0125231 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0125231 |
|---|---|
| container_issue | 6 |
| container_start_page | e0125231 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Kimura, Tomoki Takahashi, Shigeo Takahashi, Ippei Nishibuchi, Ikuno Doi, Yoshiko Kenjo, Masahiro Murakami, Yuji Honda, Yohji Aikata, Hiroshi Chayama, Kazuaki Nagata, Yasushi |
| description | This study aimed to evaluate the dynamic computed tomographic (CT) appearance of focal radiation injury to cirrhotic liver tissue around the tumor following stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC). Seventy-seven patients with 92 HCCs were observed for >6 months. Sixty-four and 13 patients belonged to Child-Pugh class A and B, respectively. The median SBRT dose was 48 Gy/4fr. Dynamic CT scans were performed in non-enhanced, arterial, portal, and venous phases. The median follow-up period was 18 months. Dynamic CT appearances were classified into 3 types: type 1, hyperdensity in all enhanced phases; type 2, hypodensity in arterial and portal phases; type 3, isodensity in all enhanced phases. Half of the type 2 or 3 appearances significantly changed to type 1, particularly in patients belonging to Child-Pugh class A. After 3-6 months, Child-Pugh class B was a significant factor in type 3 patients. Thus, dynamic CT appearances were classified into 3 patterns and significantly changed over time into the enhancement group (type 1) in most patients belonging to Child-Pugh class A. Child-Pugh class B was a significant factor in the non-enhancement group (type 3). |
| doi_str_mv | 10.1371/journal.pone.0125231 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1687640474</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A417544999</galeid><doaj_id>oai_doaj_org_article_597c9cc4e92348d2a06166bc05c126ed</doaj_id><sourcerecordid>A417544999</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-2f700250df48260175b6c4ec83c1315002f573ee737d10b9f867bbcad097beab3</originalsourceid><addsrcrecordid>eNqNk91u0zAUxyMEYqPwBggsISG4aLHjxE5ukEphrFKlSVvh1nKck9ZVEme2M-hb8Yg4bTe1aBcoUhKd8zv_82GfKHpN8IRQTj5tTG9bWU8608IEkziNKXkSnZOcxmMWY_r06P8seuHcBuOUZow9j85ihhnHLD2P_izXgJa6ATQLeg6QqdDXbSsbrYKl6XoPJVqaxqys7NbBOO06kFa2aodey1JLr02L5u2mt1vkDfJBcaatXRsf-IW-A4suTF2bX7pdoRsPFoyXanB-MeX2SCPUErJsUWUsuoROeqOgrvtaWjSTVunWNPJl9KyStYNXh-8o-nHxbTm7HC-uvs9n08VY8TTz47jiGMcpLqskC90SnhZMJaAyqgglafBVKacAnPKS4CKvMsaLQskS57wAWdBR9Hav29XGicOwnSAs4yzBCU8CMd8TpZEb0VndSLsVRmqxMxi7EtKGLmsQac5VrkL-PKZJVsYSM8JYoXCqSMygDFqfD9n6ooFSQeutrE9ETz2tXouVuRNJwsIBD8V8OAhYc9uD86LRbpiebMH0u7pzSggJ71H07h_08e4O1EqGBnRbmZBXDaJimoRxJkmeD1qTR6jwlBBuULiZlQ72k4CPJwGB8fDbr2TvnJjfXP8_e_XzlH1_xK5B1n7tTN0P98qdgskeVNY4Z6F6GDLBYlis-2mIYbHEYbFC2JvjA3oIut8k-hdcPiA0</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1687640474</pqid></control><display><type>article</type><title>The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Kimura, Tomoki ; Takahashi, Shigeo ; Takahashi, Ippei ; Nishibuchi, Ikuno ; Doi, Yoshiko ; Kenjo, Masahiro ; Murakami, Yuji ; Honda, Yohji ; Aikata, Hiroshi ; Chayama, Kazuaki ; Nagata, Yasushi</creator><creatorcontrib>Kimura, Tomoki ; Takahashi, Shigeo ; Takahashi, Ippei ; Nishibuchi, Ikuno ; Doi, Yoshiko ; Kenjo, Masahiro ; Murakami, Yuji ; Honda, Yohji ; Aikata, Hiroshi ; Chayama, Kazuaki ; Nagata, Yasushi</creatorcontrib><description>This study aimed to evaluate the dynamic computed tomographic (CT) appearance of focal radiation injury to cirrhotic liver tissue around the tumor following stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC). Seventy-seven patients with 92 HCCs were observed for >6 months. Sixty-four and 13 patients belonged to Child-Pugh class A and B, respectively. The median SBRT dose was 48 Gy/4fr. Dynamic CT scans were performed in non-enhanced, arterial, portal, and venous phases. The median follow-up period was 18 months. Dynamic CT appearances were classified into 3 types: type 1, hyperdensity in all enhanced phases; type 2, hypodensity in arterial and portal phases; type 3, isodensity in all enhanced phases. Half of the type 2 or 3 appearances significantly changed to type 1, particularly in patients belonging to Child-Pugh class A. After 3-6 months, Child-Pugh class B was a significant factor in type 3 patients. Thus, dynamic CT appearances were classified into 3 patterns and significantly changed over time into the enhancement group (type 1) in most patients belonging to Child-Pugh class A. Child-Pugh class B was a significant factor in the non-enhancement group (type 3).</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0125231</identifier><identifier>PMID: 26067065</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Antineoplastic agents ; Biomedical research ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Care and treatment ; Computation ; Computed tomography ; Drug dosages ; Female ; Hepatitis ; Hepatocellular carcinoma ; Humans ; Liver ; Liver - diagnostic imaging ; Liver - radiation effects ; Liver cancer ; Liver cirrhosis ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - etiology ; Liver diseases ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Medical imaging ; Middle Aged ; Multivariate analysis ; Oncology ; Patients ; Phases ; Radiation ; Radiation (Physics) ; Radiation injuries ; Radiation therapy ; Radiosurgery - adverse effects ; Radiotherapy ; Radiotherapy Dosage ; Retrospective Studies ; Science ; Tomography, X-Ray Computed - methods ; Tumors</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0125231-e0125231</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Kimura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Kimura et al 2015 Kimura et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-2f700250df48260175b6c4ec83c1315002f573ee737d10b9f867bbcad097beab3</citedby><cites>FETCH-LOGICAL-c758t-2f700250df48260175b6c4ec83c1315002f573ee737d10b9f867bbcad097beab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466204/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466204/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26067065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimura, Tomoki</creatorcontrib><creatorcontrib>Takahashi, Shigeo</creatorcontrib><creatorcontrib>Takahashi, Ippei</creatorcontrib><creatorcontrib>Nishibuchi, Ikuno</creatorcontrib><creatorcontrib>Doi, Yoshiko</creatorcontrib><creatorcontrib>Kenjo, Masahiro</creatorcontrib><creatorcontrib>Murakami, Yuji</creatorcontrib><creatorcontrib>Honda, Yohji</creatorcontrib><creatorcontrib>Aikata, Hiroshi</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Nagata, Yasushi</creatorcontrib><title>The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to evaluate the dynamic computed tomographic (CT) appearance of focal radiation injury to cirrhotic liver tissue around the tumor following stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC). Seventy-seven patients with 92 HCCs were observed for >6 months. Sixty-four and 13 patients belonged to Child-Pugh class A and B, respectively. The median SBRT dose was 48 Gy/4fr. Dynamic CT scans were performed in non-enhanced, arterial, portal, and venous phases. The median follow-up period was 18 months. Dynamic CT appearances were classified into 3 types: type 1, hyperdensity in all enhanced phases; type 2, hypodensity in arterial and portal phases; type 3, isodensity in all enhanced phases. Half of the type 2 or 3 appearances significantly changed to type 1, particularly in patients belonging to Child-Pugh class A. After 3-6 months, Child-Pugh class B was a significant factor in type 3 patients. Thus, dynamic CT appearances were classified into 3 patterns and significantly changed over time into the enhancement group (type 1) in most patients belonging to Child-Pugh class A. Child-Pugh class B was a significant factor in the non-enhancement group (type 3).</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic agents</subject><subject>Biomedical research</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Care and treatment</subject><subject>Computation</subject><subject>Computed tomography</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Hepatitis</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - radiation effects</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver diseases</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Patients</subject><subject>Phases</subject><subject>Radiation</subject><subject>Radiation (Physics)</subject><subject>Radiation injuries</subject><subject>Radiation therapy</subject><subject>Radiosurgery - adverse effects</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk91u0zAUxyMEYqPwBggsISG4aLHjxE5ukEphrFKlSVvh1nKck9ZVEme2M-hb8Yg4bTe1aBcoUhKd8zv_82GfKHpN8IRQTj5tTG9bWU8608IEkziNKXkSnZOcxmMWY_r06P8seuHcBuOUZow9j85ihhnHLD2P_izXgJa6ATQLeg6QqdDXbSsbrYKl6XoPJVqaxqys7NbBOO06kFa2aodey1JLr02L5u2mt1vkDfJBcaatXRsf-IW-A4suTF2bX7pdoRsPFoyXanB-MeX2SCPUErJsUWUsuoROeqOgrvtaWjSTVunWNPJl9KyStYNXh-8o-nHxbTm7HC-uvs9n08VY8TTz47jiGMcpLqskC90SnhZMJaAyqgglafBVKacAnPKS4CKvMsaLQskS57wAWdBR9Hav29XGicOwnSAs4yzBCU8CMd8TpZEb0VndSLsVRmqxMxi7EtKGLmsQac5VrkL-PKZJVsYSM8JYoXCqSMygDFqfD9n6ooFSQeutrE9ETz2tXouVuRNJwsIBD8V8OAhYc9uD86LRbpiebMH0u7pzSggJ71H07h_08e4O1EqGBnRbmZBXDaJimoRxJkmeD1qTR6jwlBBuULiZlQ72k4CPJwGB8fDbr2TvnJjfXP8_e_XzlH1_xK5B1n7tTN0P98qdgskeVNY4Z6F6GDLBYlis-2mIYbHEYbFC2JvjA3oIut8k-hdcPiA0</recordid><startdate>20150611</startdate><enddate>20150611</enddate><creator>Kimura, Tomoki</creator><creator>Takahashi, Shigeo</creator><creator>Takahashi, Ippei</creator><creator>Nishibuchi, Ikuno</creator><creator>Doi, Yoshiko</creator><creator>Kenjo, Masahiro</creator><creator>Murakami, Yuji</creator><creator>Honda, Yohji</creator><creator>Aikata, Hiroshi</creator><creator>Chayama, Kazuaki</creator><creator>Nagata, Yasushi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150611</creationdate><title>The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma</title><author>Kimura, Tomoki ; Takahashi, Shigeo ; Takahashi, Ippei ; Nishibuchi, Ikuno ; Doi, Yoshiko ; Kenjo, Masahiro ; Murakami, Yuji ; Honda, Yohji ; Aikata, Hiroshi ; Chayama, Kazuaki ; Nagata, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-2f700250df48260175b6c4ec83c1315002f573ee737d10b9f867bbcad097beab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic agents</topic><topic>Biomedical research</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Care and treatment</topic><topic>Computation</topic><topic>Computed tomography</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - radiation effects</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver diseases</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Patients</topic><topic>Phases</topic><topic>Radiation</topic><topic>Radiation (Physics)</topic><topic>Radiation injuries</topic><topic>Radiation therapy</topic><topic>Radiosurgery - adverse effects</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimura, Tomoki</creatorcontrib><creatorcontrib>Takahashi, Shigeo</creatorcontrib><creatorcontrib>Takahashi, Ippei</creatorcontrib><creatorcontrib>Nishibuchi, Ikuno</creatorcontrib><creatorcontrib>Doi, Yoshiko</creatorcontrib><creatorcontrib>Kenjo, Masahiro</creatorcontrib><creatorcontrib>Murakami, Yuji</creatorcontrib><creatorcontrib>Honda, Yohji</creatorcontrib><creatorcontrib>Aikata, Hiroshi</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Nagata, Yasushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, Tomoki</au><au>Takahashi, Shigeo</au><au>Takahashi, Ippei</au><au>Nishibuchi, Ikuno</au><au>Doi, Yoshiko</au><au>Kenjo, Masahiro</au><au>Murakami, Yuji</au><au>Honda, Yohji</au><au>Aikata, Hiroshi</au><au>Chayama, Kazuaki</au><au>Nagata, Yasushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-11</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0125231</spage><epage>e0125231</epage><pages>e0125231-e0125231</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to evaluate the dynamic computed tomographic (CT) appearance of focal radiation injury to cirrhotic liver tissue around the tumor following stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC). Seventy-seven patients with 92 HCCs were observed for >6 months. Sixty-four and 13 patients belonged to Child-Pugh class A and B, respectively. The median SBRT dose was 48 Gy/4fr. Dynamic CT scans were performed in non-enhanced, arterial, portal, and venous phases. The median follow-up period was 18 months. Dynamic CT appearances were classified into 3 types: type 1, hyperdensity in all enhanced phases; type 2, hypodensity in arterial and portal phases; type 3, isodensity in all enhanced phases. Half of the type 2 or 3 appearances significantly changed to type 1, particularly in patients belonging to Child-Pugh class A. After 3-6 months, Child-Pugh class B was a significant factor in type 3 patients. Thus, dynamic CT appearances were classified into 3 patterns and significantly changed over time into the enhancement group (type 1) in most patients belonging to Child-Pugh class A. Child-Pugh class B was a significant factor in the non-enhancement group (type 3).</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26067065</pmid><doi>10.1371/journal.pone.0125231</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-06, Vol.10 (6), p.e0125231-e0125231 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1687640474 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Aged Aged, 80 and over Antineoplastic agents Biomedical research Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Care and treatment Computation Computed tomography Drug dosages Female Hepatitis Hepatocellular carcinoma Humans Liver Liver - diagnostic imaging Liver - radiation effects Liver cancer Liver cirrhosis Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - etiology Liver diseases Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Liver Neoplasms - surgery Male Medical imaging Middle Aged Multivariate analysis Oncology Patients Phases Radiation Radiation (Physics) Radiation injuries Radiation therapy Radiosurgery - adverse effects Radiotherapy Radiotherapy Dosage Retrospective Studies Science Tomography, X-Ray Computed - methods Tumors |
| title | The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T20%3A38%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Time%20Course%20of%20Dynamic%20Computed%20Tomographic%20Appearance%20of%20Radiation%20Injury%20to%20the%20Cirrhotic%20Liver%20Following%20Stereotactic%20Body%20Radiation%20Therapy%20for%20Hepatocellular%20Carcinoma&rft.jtitle=PloS%20one&rft.au=Kimura,%20Tomoki&rft.date=2015-06-11&rft.volume=10&rft.issue=6&rft.spage=e0125231&rft.epage=e0125231&rft.pages=e0125231-e0125231&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0125231&rft_dat=%3Cgale_plos_%3EA417544999%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1687640474&rft_id=info:pmid/26067065&rft_galeid=A417544999&rft_doaj_id=oai_doaj_org_article_597c9cc4e92348d2a06166bc05c126ed&rfr_iscdi=true |