Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway

Constitutive activation of the Rearranged during Transfection (RET) proto-oncogene leads to the development of MEN2A medullary thyroid cancer (MTC). The relatively clear genotype/phenotype relationship seen with RET mutations and the development of MEN2A is unusual in the fact that a single gene act...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0127943-e0127943
Hauptverfasser:	Burdine, Lyle J, Burdine, Marie Schluterman, Moreland, Linley, Fogel, Brad, Orr, Lisa M, James, Jennifer, Turnage, Richard H, Tackett, Alan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analysis Biochemistry Cancer Carcinoma, Neuroendocrine - metabolism Cell cycle Cell division Cell Line, Tumor Chemoresistance Chemotherapy Chromatin Damage detection Deoxyribonucleic acid DNA DNA damage DNA-Activated Protein Kinase - metabolism DNA-dependent protein kinase Gene expression Gene Expression Regulation, Neoplastic Genotypes Histones Humans Indoles - pharmacology Kinases Ligands Metastases Metastasis Molecular biology Mutation Neural crest Nuclear Proteins - metabolism Phenotypes Phosphatase Phosphorylation Phosphorylation - drug effects Protein kinase C Proteins Proteomics - methods Proto-Oncogene Proteins c-ret - metabolism Ret protein Serine Signal Transduction Signaling Thyroid Thyroid cancer Thyroid Neoplasms - metabolism Transfection Tumors Tyrosine kinase inhibitors
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