Tyrosol Suppresses Allergic Inflammation by Inhibiting the Activation of Phosphoinositide 3-Kinase in Mast Cells

Allergic diseases such as atopic dermatitis, rhinitis, asthma, and anaphylaxis are attractive research areas. Tyrosol (2-(4-hydroxyphenyl)ethanol) is a polyphenolic compound with diverse biological activities. In this study, we investigated whether tyrosol has anti-allergic inflammatory effects. Ova...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0129829-e0129829
Hauptverfasser:	Je, In-Gyu, Kim, Duk-Sil, Kim, Sung-Wan, Lee, Soyoung, Lee, Hyun-Shik, Park, Eui Kyun, Khang, Dongwoo, Kim, Sang-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation AKT protein Allergic diseases Analysis Anaphylaxis Animal models Animals Anti-Allergic Agents - pharmacology Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Apoptosis - drug effects Asthma Atopic dermatitis Blotting, Western Calcium Calcium (intracellular) Calcium influx Cell activation Cell Degranulation - drug effects Cell Proliferation - drug effects Cells, Cultured Cytokines Cytokines - genetics Cytokines - metabolism Degranulation Dermatitis Enzyme Activation - drug effects Enzyme inhibitors Enzyme-Linked Immunosorbent Assay Ethanol Hypersensitivity Hypersensitivity - enzymology Hypersensitivity - immunology Hypersensitivity - prevention & control Hypothermia Immunoglobulin E Inflammation Inflammation - enzymology Inflammation - immunology Inflammation - prevention & control Inflammatory diseases Inhibition Lyn protein Male Mast cells Mast Cells - drug effects Mast Cells - enzymology Mast Cells - immunology Mice Molecular chains Oral administration Ovalbumin Passive cutaneous anaphylaxis Passive Cutaneous Anaphylaxis - drug effects Passive Cutaneous Anaphylaxis - immunology Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Phosphoinositide-3 Kinase Inhibitors Phosphorylation Phosphorylation - drug effects Pigmentation Proteins Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Regulators Reverse Transcriptase Polymerase Chain Reaction Rhinitis RNA, Messenger - genetics
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