Investigation of Gene Regulatory Networks Associated with Autism Spectrum Disorder Based on MiRNA Expression in China
Autism spectrum disorder (ASD) comprise a group of neurodevelopmental disorders characterized by deficits in social and communication capacities and repetitive behaviors. Increasing neuroscientific evidence indicates that the neuropathology of ASD is widespread and involves epigenetic regulation in...
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| creator | Huang, Fengzhen Long, Zhe Chen, Zhao Li, Jiada Hu, Zhengmao Qiu, Rong Zhuang, Wei Tang, Beisha Xia, Kun Jiang, Hong |
| description | Autism spectrum disorder (ASD) comprise a group of neurodevelopmental disorders characterized by deficits in social and communication capacities and repetitive behaviors. Increasing neuroscientific evidence indicates that the neuropathology of ASD is widespread and involves epigenetic regulation in the brain. Differentially expressed miRNAs in the peripheral blood from autism patients were identified by high-throughput miRNA microarray analyses. Five of these miRNAs were confirmed through quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis. A search for candidate target genes of the five confirmed miRNAs was performed through a Kyoto encyclopedia of genes and genomes (KEGG) biological pathways and Gene Ontology enrichment analysis of gene function to identify gene regulatory networks. To the best of our knowledge, this study provides the first global miRNA expression profile of ASD in China. The differentially expressed miR-34b may potentially explain the higher percentage of male ASD patients, and the aberrantly expressed miR-103a-3p may contribute to the abnormal ubiquitin-mediated proteolysis observed in ASD. |
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Increasing neuroscientific evidence indicates that the neuropathology of ASD is widespread and involves epigenetic regulation in the brain. Differentially expressed miRNAs in the peripheral blood from autism patients were identified by high-throughput miRNA microarray analyses. Five of these miRNAs were confirmed through quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis. A search for candidate target genes of the five confirmed miRNAs was performed through a Kyoto encyclopedia of genes and genomes (KEGG) biological pathways and Gene Ontology enrichment analysis of gene function to identify gene regulatory networks. To the best of our knowledge, this study provides the first global miRNA expression profile of ASD in China. The differentially expressed miR-34b may potentially explain the higher percentage of male ASD patients, and the aberrantly expressed miR-103a-3p may contribute to the abnormal ubiquitin-mediated proteolysis observed in ASD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0129052</identifier><identifier>PMID: 26061495</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Analysis ; Asian Continental Ancestry Group - genetics ; Autism ; Autism Spectrum Disorder - blood ; Autism Spectrum Disorder - genetics ; Brain ; Brain research ; Brain-derived neurotrophic factor ; Child ; Child, Preschool ; China ; DNA microarrays ; Encyclopedias ; Epigenesis, Genetic ; Epigenetic inheritance ; Female ; Gene expression ; Gene Expression Profiling - methods ; Gene Regulatory Networks ; Genes ; Genetic aspects ; Genetic Association Studies ; Genetics ; Genomes ; Genomics ; Growth factors ; Hospitals ; Humans ; Investigations ; Laboratories ; Male ; Metabolism ; MicroRNA ; MicroRNAs ; MicroRNAs - blood ; MicroRNAs - genetics ; miRNA ; Neurodevelopmental disorders ; Neurology ; Oligonucleotide Array Sequence Analysis - methods ; Patients ; Peripheral blood ; Polymerase chain reaction ; Proteolysis ; Psychiatry ; Reverse transcription ; Studies ; Thoracic surgery ; Ubiquitin ; Ubiquitin - metabolism</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0129052-e0129052</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Huang et al 2015 Huang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ed0eeafbebf1d340af49677ae3caefc9a87eb68733c9751c054b12794dccaf243</citedby><cites>FETCH-LOGICAL-c692t-ed0eeafbebf1d340af49677ae3caefc9a87eb68733c9751c054b12794dccaf243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462583/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462583/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26061495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Fengzhen</creatorcontrib><creatorcontrib>Long, Zhe</creatorcontrib><creatorcontrib>Chen, Zhao</creatorcontrib><creatorcontrib>Li, Jiada</creatorcontrib><creatorcontrib>Hu, Zhengmao</creatorcontrib><creatorcontrib>Qiu, Rong</creatorcontrib><creatorcontrib>Zhuang, Wei</creatorcontrib><creatorcontrib>Tang, Beisha</creatorcontrib><creatorcontrib>Xia, Kun</creatorcontrib><creatorcontrib>Jiang, Hong</creatorcontrib><title>Investigation of Gene Regulatory Networks Associated with Autism Spectrum Disorder Based on MiRNA Expression in China</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Autism spectrum disorder (ASD) comprise a group of neurodevelopmental disorders characterized by deficits in social and communication capacities and repetitive behaviors. Increasing neuroscientific evidence indicates that the neuropathology of ASD is widespread and involves epigenetic regulation in the brain. Differentially expressed miRNAs in the peripheral blood from autism patients were identified by high-throughput miRNA microarray analyses. Five of these miRNAs were confirmed through quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis. A search for candidate target genes of the five confirmed miRNAs was performed through a Kyoto encyclopedia of genes and genomes (KEGG) biological pathways and Gene Ontology enrichment analysis of gene function to identify gene regulatory networks. To the best of our knowledge, this study provides the first global miRNA expression profile of ASD in China. The differentially expressed miR-34b may potentially explain the higher percentage of male ASD patients, and the aberrantly expressed miR-103a-3p may contribute to the abnormal ubiquitin-mediated proteolysis observed in ASD.</description><subject>Age</subject><subject>Analysis</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - blood</subject><subject>Autism Spectrum Disorder - genetics</subject><subject>Brain</subject><subject>Brain research</subject><subject>Brain-derived neurotrophic factor</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China</subject><subject>DNA microarrays</subject><subject>Encyclopedias</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetic inheritance</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Regulatory Networks</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genetics</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Growth factors</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Investigations</subject><subject>Laboratories</subject><subject>Male</subject><subject>Metabolism</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Neurodevelopmental disorders</subject><subject>Neurology</subject><subject>Oligonucleotide Array Sequence Analysis - methods</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>Polymerase chain reaction</subject><subject>Proteolysis</subject><subject>Psychiatry</subject><subject>Reverse transcription</subject><subject>Studies</subject><subject>Thoracic surgery</subject><subject>Ubiquitin</subject><subject>Ubiquitin - metabolism</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYqPwDxBYQkJw0RInTtLcIJUyRqWxSR1wa504x6lLEhfb2ce_x6HZ1KBdIFuyZT_ve-xjnyB4ScMZjTP6Yas700I92-kWZyGN8jCJHgXHNI-jaRqF8eOD-VHwzNptGCbxPE2fBkdRGqaU5clx0K3aK7ROVeCUbomW5BRbJGusuhqcNrfkHN21Nr8sWVirhQKHJblWbkMWnVO2IZc7FM50DfmsrDYlGvIJrGe82ze1Pl-Qk5udQWt7e9WS5Ua18Dx4IqG2-GIYJ8GPLyffl1-nZxenq-XibCrSPHJTLENEkAUWkpYxC0GyPM0ywFgASpHDPMMinWdxLPIsoSJMWEGjLGelECAjFk-C13vfXa0tHzJmOe01adpnZhKs9kSpYct3RjVgbrkGxf8uaFNxME6JGnkmCiaZkF5HmYhKAEyLsphDmYQyk9R7fRyidUWDpcDWGahHpuOdVm14pa84Y2mUzGNv8G4wMPp355-FN8oKrGtoUXf7c-d5QvP-3G_-QR--3UBV4C-gWql9XNGb8gWjme9Rnnlq9gDlW4mNEv57SeXXR4L3I4FnHN64Cjpr-epy_f_sxc8x-_aA3SDUbmN13fVf045BtgeF0dYalPdJpiHvq-MuG7yvDj5Uh5e9Onyge9FdOcR_AI6eDJM</recordid><startdate>20150610</startdate><enddate>20150610</enddate><creator>Huang, Fengzhen</creator><creator>Long, Zhe</creator><creator>Chen, Zhao</creator><creator>Li, Jiada</creator><creator>Hu, Zhengmao</creator><creator>Qiu, Rong</creator><creator>Zhuang, Wei</creator><creator>Tang, Beisha</creator><creator>Xia, Kun</creator><creator>Jiang, Hong</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150610</creationdate><title>Investigation of Gene Regulatory Networks Associated with Autism Spectrum Disorder Based on MiRNA Expression in China</title><author>Huang, Fengzhen ; Long, Zhe ; Chen, Zhao ; Li, Jiada ; Hu, Zhengmao ; Qiu, Rong ; Zhuang, Wei ; Tang, Beisha ; Xia, Kun ; Jiang, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ed0eeafbebf1d340af49677ae3caefc9a87eb68733c9751c054b12794dccaf243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age</topic><topic>Analysis</topic><topic>Asian Continental Ancestry Group - 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Increasing neuroscientific evidence indicates that the neuropathology of ASD is widespread and involves epigenetic regulation in the brain. Differentially expressed miRNAs in the peripheral blood from autism patients were identified by high-throughput miRNA microarray analyses. Five of these miRNAs were confirmed through quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis. A search for candidate target genes of the five confirmed miRNAs was performed through a Kyoto encyclopedia of genes and genomes (KEGG) biological pathways and Gene Ontology enrichment analysis of gene function to identify gene regulatory networks. To the best of our knowledge, this study provides the first global miRNA expression profile of ASD in China. The differentially expressed miR-34b may potentially explain the higher percentage of male ASD patients, and the aberrantly expressed miR-103a-3p may contribute to the abnormal ubiquitin-mediated proteolysis observed in ASD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26061495</pmid><doi>10.1371/journal.pone.0129052</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Age Analysis Asian Continental Ancestry Group - genetics Autism Autism Spectrum Disorder - blood Autism Spectrum Disorder - genetics Brain Brain research Brain-derived neurotrophic factor Child Child, Preschool China DNA microarrays Encyclopedias Epigenesis, Genetic Epigenetic inheritance Female Gene expression Gene Expression Profiling - methods Gene Regulatory Networks Genes Genetic aspects Genetic Association Studies Genetics Genomes Genomics Growth factors Hospitals Humans Investigations Laboratories Male Metabolism MicroRNA MicroRNAs MicroRNAs - blood MicroRNAs - genetics miRNA Neurodevelopmental disorders Neurology Oligonucleotide Array Sequence Analysis - methods Patients Peripheral blood Polymerase chain reaction Proteolysis Psychiatry Reverse transcription Studies Thoracic surgery Ubiquitin Ubiquitin - metabolism |
| title | Investigation of Gene Regulatory Networks Associated with Autism Spectrum Disorder Based on MiRNA Expression in China |
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