Activation of Blood Coagulation in Two Prototypic Autoimmune Skin Diseases: A Possible Link with Thrombotic Risk

Coagulation activation has been demonstrated in two prototypic autoimmune skin diseases, chronic autoimmune urticaria and bullous pemphigoid, but only the latter is associated with increased thrombotic risk. Two markers of coagulation activation (prothrombin fragment F1+2 and fibrin fragment D-dimer...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0129456-e0129456
Hauptverfasser:	Cugno, Massimo, Tedeschi, Alberto, Borghi, Alessandro, Bucciarelli, Paolo, Asero, Riccardo, Venegoni, Luigia, Griffini, Samantha, Grovetti, Elena, Berti, Emilio, Marzano, Angelo Valerio
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adult Autoimmune Diseases - metabolism Autoimmune Diseases - pathology B cells Blood coagulation Blood Coagulation - physiology Bullous pemphigoid Clinical trials Coagulation Dermatology Disease Diseases Disorders Female Fibrin Fibrin Fibrinogen Degradation Products - metabolism Histamine Humans Immunohistochemistry Inflammation Male Measurement methods Medical research Medical treatment Middle Aged Pathogenesis Patients Pemphigoid Pemphigoid, Bullous - metabolism Peptide Fragments - metabolism Prothrombin Prothrombin - metabolism Remission Risk Skin Skin - metabolism Skin - pathology Skin diseases Skin Diseases - metabolism Skin Diseases - pathology Skin tests Skin Tests - methods Thrombin Thromboplastin - metabolism Thrombosis Thrombosis - metabolism Thrombosis - pathology Tissue factor Tumor necrosis factor-TNF Urticaria Urticaria - metabolism Urticaria - pathology Young Adult
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