Trypanosoma cruzi Intracellular Amastigotes Isolated by Nitrogen Decompression Are Capable of Endocytosis and Cargo Storage in Reservosomes

Epimastigote forms of Trypanosoma cruzi (the etiologic agent of Chagas disease) internalize and store extracellular macromolecules in lysosome-related organelles (LROs) called reservosomes, which are positive for the cysteine protease cruzipain. Despite the importance of endocytosis for cell prolife...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130165-e0130165
Hauptverfasser:	Batista, Cassiano Martin, Kessler, Rafael Luis, Eger, Iriane, Soares, Maurilio José
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Albumin Amastigotes Animals Binding Blotting, Western Cavitation Cell division Cell proliferation Cercopithecus aethiops Chagas disease Chromatography Cruzipain Cysteine Cysteine Endopeptidases Cysteine proteinase Cytometry Decompression Dissociation Endocytosis Endocytosis - drug effects Endosomes - drug effects Endosomes - metabolism Etiology Flow Cytometry Fluorescence Fluorescent Dyes - metabolism Immunofluorescence Internalization Intracellular Intracellular Space - parasitology Laboratories Life Cycle Stages - drug effects Lysosomes - metabolism Macromolecules Mice Microscopy Microscopy, Fluorescence Models, Biological NIH 3T3 Cells Nitrogen Nitrogen - pharmacology Organelles Parasites Proteases Protozoa Serum Albumin, Bovine - metabolism Transferrin Transferrin - metabolism Transferrins Trypanosoma cruzi Trypanosoma cruzi - growth & development Trypanosoma cruzi - isolation & purification Vector-borne diseases Vero Cells Western blotting
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