BRAF Mutations in Canine Cancers

Activating mutations of the BRAF gene lead to constitutive activation of the MAPK pathway. Although many human cancers carry the mutated BRAF gene, this mutation has not yet been characterized in canine cancers. As human and canine cancers share molecular abnormalities, we hypothesized that BRAF gen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0129534-e0129534
Hauptverfasser:	Mochizuki, Hiroyuki, Kennedy, Katherine, Shapiro, Susan G, Breen, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acids Activation Amino Acid Sequence Amino Acid Substitution Amino acids Analysis Animals Base Sequence Bladder cancer Cancer Conservation Deoxyribonucleic acid DNA Dogs Exons - genetics Female Gene mutation Gene sequencing Genes Genetic aspects Genetic Predisposition to Disease Glutamate Glutamic acid Humans Kinases Leukemia Male MAP kinase Medical diagnosis Medical research Melanoma Metastasis Molecular chains Molecular Sequence Data Mutation Mutation - genetics Mutation hot spots Neoplasms - genetics Neoplasms - veterinary Oncology Prostate cancer Proto-Oncogene Proteins B-raf - chemistry Proto-Oncogene Proteins B-raf - genetics Sequence Analysis, DNA Signal transduction Squamous cell carcinoma Tissue analysis Transversion Tumors Urothelial carcinoma Valine Veterinary colleges Veterinary medicine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!