Risk Factors Associated with Colorectal Cancer in a Subset of Patients with Mutations in MLH1 and MSH2 in Taiwan Fulfilling the Amsterdam II Criteria for Lynch Syndrome

Lynch syndrome, caused by germline mutations in mismatch repair genes, is a predisposing factor for colorectal cancer (CRC). This retrospective cohort study investigated the risk factors associated with the development of CRC in patients with MLH1 and MSH2 germline mutations. In total, 301 MLH1 and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130018-e0130018
Hauptverfasser:	Kamiza, Abram Bunya, Hsieh, Ling-Ling, Tang, Reiping, Chien, Huei-Tzu, Lai, Chih-Hsiung, Chiu, Li-Ling, Lo, Tsai-Ping, Hung, Kuan-Yi, Wang, Chun-Yi, You, Jeng-Fu, Hsiung, Chao A, Yeh, Chih-Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adult Alcohol use Blood Blood groups Cancer Cancer patients Carriers Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Confidence intervals Consortia Covariance Demography Diet DNA Mismatch Repair - genetics Epidemiology Exercise Family medical history Female Fruits Gene mutation Genes Genetic aspects Genetic disorders Genetic Predisposition to Disease Germ-Line Mutation - genetics Health risk assessment Health risks Health sciences Hospitals Humans Identification methods Life Style Lifestyles Male Medical research Medical screening Medicine Middle Aged Minority & ethnic groups Mismatch repair MLH1 protein MSH2 protein Multivariate Analysis Mutation MutL Protein Homolog 1 MutS Homolog 2 Protein - genetics Nuclear Proteins - genetics Nutrition Occupations Patients Physical activity Population Proportional Hazards Models Public health Risk analysis Risk Factors Smoking Statistical models Studies Taiwan
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!