Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of HIV Microbicide Candidates

Inflammation and immune activation of the cervicovaginal mucosa are considered factors that increase susceptibility to HIV infection. Therefore, it is essential to screen candidate anti-HIV microbicides for potential mucosal immunomodulatory/inflammatory effects prior to further clinical development...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0128557-e0128557
Hauptverfasser:	Zalenskaya, Irina A, Joseph, Theresa, Bavarva, Jasmin, Yousefieh, Nazita, Jackson, Suzanne S, Fashemi, Titilayo, Yamamoto, Hidemi S, Settlage, Robert, Fichorova, Raina N, Doncel, Gustavo F
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Bacteria Bacteria - drug effects Bacteria - growth & development Bioinformatics Biology Biomarkers Biomarkers - metabolism Cancer Cell Line Cellulose Clinical trials Cluster Analysis Colony Count, Microbial Comparative analysis Data processing Deregulation Disease transmission DNA microarrays Drug Evaluation, Preclinical Evaluation Female Functional analysis Gene expression Gene Expression Profiling Gene Regulatory Networks - drug effects Genes Gynecology Health aspects HIV HIV infections HIV Infections - drug therapy Human immunodeficiency virus Humans Immune response Immunologic Factors - pharmacology Immunomodulation In vitro methods and tests Infections Inflammation Inflammation - pathology Laboratories Lymphocytes Medical research Medical schools Microbial Sensitivity Tests Microbicides Microbiota Microbiota (Symbiotic organisms) Models, Biological Mucosa Mucous Membrane - drug effects Mucous Membrane - pathology NF-kappa B - metabolism NF-κB protein Obstetrics Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Reproducibility of Results Risk factors Transcription, Genetic - drug effects Vagina Vagina - cytology Vagina - microbiology Vaginosis Young adults
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