Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics

Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, inflict an enormous health care burden on society. Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune inflammatory disease, both lead to irreversible struct...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0127165-e0127165
Hauptverfasser:	Natarajan, Venkatachalam, Madhan, Balaraman, Tiku, Moti L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - etiology Arthritis, Experimental - pathology Biocompatibility Biomedical materials Breakdowns Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Catechin Cattle Chondroitin sulfate Collagen Collagen (type II) Collagen - analysis Collagen Type II - toxicity Collagenase Collagenases - metabolism Collagens Compressive Strength Crosslinking Degradation Diabetes Digestion Enzymes Epigallocatechin gallate Explants Female Glycosaminoglycans Glycosaminoglycans - analysis Health care Industrial research Inflammation Injections, Intra-Articular Laboratory animals Mucopolysaccharides Older people Osteoarthritis Polymer crosslinking Polyphenols Polyphenols - therapeutic use Protective Agents - pharmacology Protective Agents - therapeutic use Quercetin Rats Rats, Wistar Reduction Rheumatoid arthritis Rheumatoid factor Scoring Stability analysis Structural damage Structure-function relationships Tannic acid Thermal stability
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