Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics
Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, inflict an enormous health care burden on society. Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune inflammatory disease, both lead to irreversible struct...
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| description | Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, inflict an enormous health care burden on society. Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune inflammatory disease, both lead to irreversible structural and functional damage to articular cartilage. The aim of this study was to investigate the effect of polyphenols such as catechin, quercetin, epigallocatechin gallate, and tannic acid, on crosslinking type II collagen and the roles of these agents in managing in vivo articular cartilage degradation. The thermal, enzymatic, and physical stability of bovine articular cartilage explants following polyphenolic treatment were assessed for efficiency. Epigallocatechin gallate and tannic acid-treated explants showed >12 °C increase over native cartilage in thermal stability, thereby confirming cartilage crosslinking. Polyphenol-treated cartilage also showed a significant reduction in the percentage of collagen degradation and the release of glycosaminoglycans against collagenase digestion, indicating the increase physical integrity and resistance of polyphenol crosslinked cartilage to enzymatic digestion. To examine the in vivo cartilage protective effects, polyphenols were injected intra-articularly before (prophylactic) and after (therapeutic) the induction of collagen-induced arthritis in rats. The hind paw volume and histomorphological scoring was done for cartilage damage. The intra-articular injection of epigallocatechin gallate and tannic acid did not significantly influence the time of onset or the intensity of joint inflammation. However, histomorphological scoring of the articular cartilage showed a significant reduction in cartilage degradation in prophylactic- and therapeutic-groups, indicating that intra-articular injections of polyphenols bind to articular cartilage and making it resistant to degradation despite ongoing inflammation. These studies establish the value of intra-articular injections of polyphenol in stabilization of cartilage collagen against degradation and indicate the unique beneficial role of injectable polyphenols in protecting the cartilage in arthritic conditions. |
| doi_str_mv | 10.1371/journal.pone.0127165 |
| format | Article |
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Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune inflammatory disease, both lead to irreversible structural and functional damage to articular cartilage. The aim of this study was to investigate the effect of polyphenols such as catechin, quercetin, epigallocatechin gallate, and tannic acid, on crosslinking type II collagen and the roles of these agents in managing in vivo articular cartilage degradation. The thermal, enzymatic, and physical stability of bovine articular cartilage explants following polyphenolic treatment were assessed for efficiency. Epigallocatechin gallate and tannic acid-treated explants showed >12 °C increase over native cartilage in thermal stability, thereby confirming cartilage crosslinking. Polyphenol-treated cartilage also showed a significant reduction in the percentage of collagen degradation and the release of glycosaminoglycans against collagenase digestion, indicating the increase physical integrity and resistance of polyphenol crosslinked cartilage to enzymatic digestion. To examine the in vivo cartilage protective effects, polyphenols were injected intra-articularly before (prophylactic) and after (therapeutic) the induction of collagen-induced arthritis in rats. The hind paw volume and histomorphological scoring was done for cartilage damage. The intra-articular injection of epigallocatechin gallate and tannic acid did not significantly influence the time of onset or the intensity of joint inflammation. However, histomorphological scoring of the articular cartilage showed a significant reduction in cartilage degradation in prophylactic- and therapeutic-groups, indicating that intra-articular injections of polyphenols bind to articular cartilage and making it resistant to degradation despite ongoing inflammation. These studies establish the value of intra-articular injections of polyphenol in stabilization of cartilage collagen against degradation and indicate the unique beneficial role of injectable polyphenols in protecting the cartilage in arthritic conditions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0127165</identifier><identifier>PMID: 26046639</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Animals ; Arthritis ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - etiology ; Arthritis, Experimental - pathology ; Biocompatibility ; Biomedical materials ; Breakdowns ; Cartilage ; Cartilage (articular) ; Cartilage diseases ; Cartilage, Articular - drug effects ; Cartilage, Articular - metabolism ; Cartilage, Articular - pathology ; Catechin ; Cattle ; Chondroitin sulfate ; Collagen ; Collagen (type II) ; Collagen - analysis ; Collagen Type II - toxicity ; Collagenase ; Collagenases - metabolism ; Collagens ; Compressive Strength ; Crosslinking ; Degradation ; Diabetes ; Digestion ; Enzymes ; Epigallocatechin gallate ; Explants ; Female ; Glycosaminoglycans ; Glycosaminoglycans - analysis ; Health care ; Industrial research ; Inflammation ; Injections, Intra-Articular ; Laboratory animals ; Mucopolysaccharides ; Older people ; Osteoarthritis ; Polymer crosslinking ; Polyphenols ; Polyphenols - therapeutic use ; Protective Agents - pharmacology ; Protective Agents - therapeutic use ; Quercetin ; Rats ; Rats, Wistar ; Reduction ; Rheumatoid arthritis ; Rheumatoid factor ; Scoring ; Stability analysis ; Structural damage ; Structure-function relationships ; Tannic acid ; Thermal stability</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0127165-e0127165</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Natarajan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Natarajan et al 2015 Natarajan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8c981a760bb2fff850ca1246acf07e2e8b30e14369a5b6e56b5631e3e4cd45ab3</citedby><cites>FETCH-LOGICAL-c692t-8c981a760bb2fff850ca1246acf07e2e8b30e14369a5b6e56b5631e3e4cd45ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457493/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457493/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26046639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Natarajan, Venkatachalam</creatorcontrib><creatorcontrib>Madhan, Balaraman</creatorcontrib><creatorcontrib>Tiku, Moti L</creatorcontrib><title>Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, inflict an enormous health care burden on society. Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune inflammatory disease, both lead to irreversible structural and functional damage to articular cartilage. The aim of this study was to investigate the effect of polyphenols such as catechin, quercetin, epigallocatechin gallate, and tannic acid, on crosslinking type II collagen and the roles of these agents in managing in vivo articular cartilage degradation. The thermal, enzymatic, and physical stability of bovine articular cartilage explants following polyphenolic treatment were assessed for efficiency. Epigallocatechin gallate and tannic acid-treated explants showed >12 °C increase over native cartilage in thermal stability, thereby confirming cartilage crosslinking. Polyphenol-treated cartilage also showed a significant reduction in the percentage of collagen degradation and the release of glycosaminoglycans against collagenase digestion, indicating the increase physical integrity and resistance of polyphenol crosslinked cartilage to enzymatic digestion. To examine the in vivo cartilage protective effects, polyphenols were injected intra-articularly before (prophylactic) and after (therapeutic) the induction of collagen-induced arthritis in rats. The hind paw volume and histomorphological scoring was done for cartilage damage. The intra-articular injection of epigallocatechin gallate and tannic acid did not significantly influence the time of onset or the intensity of joint inflammation. However, histomorphological scoring of the articular cartilage showed a significant reduction in cartilage degradation in prophylactic- and therapeutic-groups, indicating that intra-articular injections of polyphenols bind to articular cartilage and making it resistant to degradation despite ongoing inflammation. These studies establish the value of intra-articular injections of polyphenol in stabilization of cartilage collagen against degradation and indicate the unique beneficial role of injectable polyphenols in protecting the cartilage in arthritic conditions.</description><subject>Acids</subject><subject>Animals</subject><subject>Arthritis</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - etiology</subject><subject>Arthritis, Experimental - pathology</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Breakdowns</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cartilage diseases</subject><subject>Cartilage, Articular - drug effects</subject><subject>Cartilage, Articular - metabolism</subject><subject>Cartilage, Articular - pathology</subject><subject>Catechin</subject><subject>Cattle</subject><subject>Chondroitin sulfate</subject><subject>Collagen</subject><subject>Collagen (type II)</subject><subject>Collagen - analysis</subject><subject>Collagen Type II - toxicity</subject><subject>Collagenase</subject><subject>Collagenases - metabolism</subject><subject>Collagens</subject><subject>Compressive Strength</subject><subject>Crosslinking</subject><subject>Degradation</subject><subject>Diabetes</subject><subject>Digestion</subject><subject>Enzymes</subject><subject>Epigallocatechin gallate</subject><subject>Explants</subject><subject>Female</subject><subject>Glycosaminoglycans</subject><subject>Glycosaminoglycans - analysis</subject><subject>Health care</subject><subject>Industrial research</subject><subject>Inflammation</subject><subject>Injections, Intra-Articular</subject><subject>Laboratory animals</subject><subject>Mucopolysaccharides</subject><subject>Older people</subject><subject>Osteoarthritis</subject><subject>Polymer crosslinking</subject><subject>Polyphenols</subject><subject>Polyphenols - therapeutic use</subject><subject>Protective Agents - pharmacology</subject><subject>Protective Agents - therapeutic use</subject><subject>Quercetin</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reduction</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Scoring</subject><subject>Stability analysis</subject><subject>Structural damage</subject><subject>Structure-function relationships</subject><subject>Tannic acid</subject><subject>Thermal stability</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggiISG42CWOD0m4QKrKaaVKrdrCrTVxxtmsHHuxE0RfhyfF6W7LLuoFykWs8ff_4xl7kuQ5yeaEFuTdyo3egpmvncV5RvKCCP4gOSQVzWciz-jDnfVB8iSEVZZxWgrxODnIRcaEoNVh8nthBw-zYz90ajTg04VdoRo6Z0PqdHruzPV6idaZkJ57N8St9C97AnFpoMVUe9dHqTbQ9zCpZwvbjAqb9CO2Hpqb2Pv0cmxbDENn2xSi94B26MCkF85g2tkdv6sleljjGDOFp8kjDSbgs-3_KPn2-dPVydfZ6dmXxcnx6UyJKh9mpapKAoXI6jrXWpc8U0ByJkDprMAcy5pmSBgVFfBaIBc1F5QgRaYaxqGmR8nLje_auCC37Q2SiFLkhBPBIrHYEI2DlVz7rgd_LR108ibgfCunCpRBqWku6qbUJeOC6YxDWbOGKFDxGIoVVfT6sM021j02Cqd7MHum-zu2W8rW_ZSM8YJVNBq82Rp492OMXZV9FxQaAxbduDl3VVWc84i--ge9v7ot1UIsoLPaxbxqMpXHjBSEFaKaqPk9VPwa7DsV36LuYnxP8HZPEJkBfw0tjCHIxeXF_7Nn3_fZ1zvsEsEMy-DMePN290G2AZV3IXjUd00mmZxG6bYbcholuR2lKHuxe0F3otvZoX8AG8AcpA</recordid><startdate>20150605</startdate><enddate>20150605</enddate><creator>Natarajan, Venkatachalam</creator><creator>Madhan, Balaraman</creator><creator>Tiku, Moti L</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150605</creationdate><title>Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics</title><author>Natarajan, Venkatachalam ; Madhan, Balaraman ; Tiku, Moti L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8c981a760bb2fff850ca1246acf07e2e8b30e14369a5b6e56b5631e3e4cd45ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acids</topic><topic>Animals</topic><topic>Arthritis</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - etiology</topic><topic>Arthritis, Experimental - pathology</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Breakdowns</topic><topic>Cartilage</topic><topic>Cartilage (articular)</topic><topic>Cartilage diseases</topic><topic>Cartilage, Articular - drug effects</topic><topic>Cartilage, Articular - metabolism</topic><topic>Cartilage, Articular - pathology</topic><topic>Catechin</topic><topic>Cattle</topic><topic>Chondroitin sulfate</topic><topic>Collagen</topic><topic>Collagen (type II)</topic><topic>Collagen - analysis</topic><topic>Collagen Type II - toxicity</topic><topic>Collagenase</topic><topic>Collagenases - metabolism</topic><topic>Collagens</topic><topic>Compressive Strength</topic><topic>Crosslinking</topic><topic>Degradation</topic><topic>Diabetes</topic><topic>Digestion</topic><topic>Enzymes</topic><topic>Epigallocatechin gallate</topic><topic>Explants</topic><topic>Female</topic><topic>Glycosaminoglycans</topic><topic>Glycosaminoglycans - analysis</topic><topic>Health care</topic><topic>Industrial research</topic><topic>Inflammation</topic><topic>Injections, Intra-Articular</topic><topic>Laboratory animals</topic><topic>Mucopolysaccharides</topic><topic>Older people</topic><topic>Osteoarthritis</topic><topic>Polymer crosslinking</topic><topic>Polyphenols</topic><topic>Polyphenols - therapeutic use</topic><topic>Protective Agents - pharmacology</topic><topic>Protective Agents - therapeutic use</topic><topic>Quercetin</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reduction</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Scoring</topic><topic>Stability analysis</topic><topic>Structural damage</topic><topic>Structure-function relationships</topic><topic>Tannic acid</topic><topic>Thermal stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Natarajan, Venkatachalam</creatorcontrib><creatorcontrib>Madhan, Balaraman</creatorcontrib><creatorcontrib>Tiku, Moti L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Natarajan, Venkatachalam</au><au>Madhan, Balaraman</au><au>Tiku, Moti L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-05</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0127165</spage><epage>e0127165</epage><pages>e0127165-e0127165</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, inflict an enormous health care burden on society. Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune inflammatory disease, both lead to irreversible structural and functional damage to articular cartilage. The aim of this study was to investigate the effect of polyphenols such as catechin, quercetin, epigallocatechin gallate, and tannic acid, on crosslinking type II collagen and the roles of these agents in managing in vivo articular cartilage degradation. The thermal, enzymatic, and physical stability of bovine articular cartilage explants following polyphenolic treatment were assessed for efficiency. Epigallocatechin gallate and tannic acid-treated explants showed >12 °C increase over native cartilage in thermal stability, thereby confirming cartilage crosslinking. Polyphenol-treated cartilage also showed a significant reduction in the percentage of collagen degradation and the release of glycosaminoglycans against collagenase digestion, indicating the increase physical integrity and resistance of polyphenol crosslinked cartilage to enzymatic digestion. To examine the in vivo cartilage protective effects, polyphenols were injected intra-articularly before (prophylactic) and after (therapeutic) the induction of collagen-induced arthritis in rats. The hind paw volume and histomorphological scoring was done for cartilage damage. The intra-articular injection of epigallocatechin gallate and tannic acid did not significantly influence the time of onset or the intensity of joint inflammation. However, histomorphological scoring of the articular cartilage showed a significant reduction in cartilage degradation in prophylactic- and therapeutic-groups, indicating that intra-articular injections of polyphenols bind to articular cartilage and making it resistant to degradation despite ongoing inflammation. These studies establish the value of intra-articular injections of polyphenol in stabilization of cartilage collagen against degradation and indicate the unique beneficial role of injectable polyphenols in protecting the cartilage in arthritic conditions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26046639</pmid><doi>10.1371/journal.pone.0127165</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1686215164 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acids Animals Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - etiology Arthritis, Experimental - pathology Biocompatibility Biomedical materials Breakdowns Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Catechin Cattle Chondroitin sulfate Collagen Collagen (type II) Collagen - analysis Collagen Type II - toxicity Collagenase Collagenases - metabolism Collagens Compressive Strength Crosslinking Degradation Diabetes Digestion Enzymes Epigallocatechin gallate Explants Female Glycosaminoglycans Glycosaminoglycans - analysis Health care Industrial research Inflammation Injections, Intra-Articular Laboratory animals Mucopolysaccharides Older people Osteoarthritis Polymer crosslinking Polyphenols Polyphenols - therapeutic use Protective Agents - pharmacology Protective Agents - therapeutic use Quercetin Rats Rats, Wistar Reduction Rheumatoid arthritis Rheumatoid factor Scoring Stability analysis Structural damage Structure-function relationships Tannic acid Thermal stability |
| title | Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T09%3A26%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intra-Articular%20Injections%20of%20Polyphenols%20Protect%20Articular%20Cartilage%20from%20Inflammation-Induced%20Degradation:%20Suggesting%20a%20Potential%20Role%20in%20Cartilage%20Therapeutics&rft.jtitle=PloS%20one&rft.au=Natarajan,%20Venkatachalam&rft.date=2015-06-05&rft.volume=10&rft.issue=6&rft.spage=e0127165&rft.epage=e0127165&rft.pages=e0127165-e0127165&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0127165&rft_dat=%3Cgale_plos_%3EA417147694%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1686215164&rft_id=info:pmid/26046639&rft_galeid=A417147694&rft_doaj_id=oai_doaj_org_article_f326bd8f84564f05a8b4d1cac8b3c479&rfr_iscdi=true |