Inhibition of NOS-NO System Prevents Autoimmune Orchitis Development in Rats: Relevance of NO Released by Testicular Macrophages in Germ Cell Apoptosis and Testosterone Secretion

Although the testis is considered an immunoprivileged organ it can orchestrate immune responses against pathological insults such as infection and trauma. Experimental autoimmune orchitis (EAO) is a model of chronic inflammation whose main histopathological features it shares with human orchitis. In...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0128709-e0128709
Hauptverfasser:	Jarazo Dietrich, Sabrina, Fass, Mónica Irina, Jacobo, Patricia Verónica, Sobarzo, Cristian Marcelo Alejandro, Lustig, Livia, Theas, María Susana
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - pharmacology Adjuvants Adjuvants, Immunologic Animals Apoptosis Apoptosis - drug effects Autoimmune Diseases - chemically induced Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune Diseases - prevention & control Blockage Cell culture Chronic infection Coculture Techniques Complex Mixtures Cysteine Degeneration Enzyme Inhibitors - pharmacology Fragments Gene Expression Regulation Health aspects Hostages Humans Immune response Immunization Inflammation Inhibition Kinases Leydig cells Leydig Cells - drug effects Leydig Cells - immunology Leydig Cells - metabolism Leydig Cells - pathology Luteinizing Hormone - blood Luteinizing Hormone - genetics Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - pathology Male NG-Nitroarginine methyl ester NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide Donors - pharmacology Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Orchitis Orchitis - chemically induced Orchitis - immunology Orchitis - pathology Orchitis - prevention & control Oxidative stress Rats Rats, Sprague-Dawley Rodents Signal Transduction Spermatozoa - drug effects Spermatozoa - immunology Spermatozoa - metabolism Spermatozoa - pathology Steroidogenesis Testes Testosterone Testosterone - biosynthesis Testosterone - secretion Trauma Triazenes - pharmacology
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