Avibirnavirus VP4 Protein Is a Phosphoprotein and Partially Contributes to the Cleavage of Intermediate Precursor VP4-VP3 Polyprotein

Birnavirus-encoded viral protein 4 (VP4) utilizes a Ser/Lys catalytic dyad mechanism to process polyprotein. Here three phosphorylated amino acid residues Ser538, Tyr611 and Thr674 within the VP4 protein of the infectious bursal disease virus (IBDV), a member of the genus Avibirnavirus of the family...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0128828-e0128828
Hauptverfasser:	Wang, Sanying, Hu, Boli, Si, Weiying, Jia, Lu, Zheng, Xiaojuan, Zhou, Jiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino Acid Motifs Amino acids Analysis Animals Antibodies, Monoclonal - chemistry Antigenic determinants Apoptosis B cells Catalysis Cell cycle Cell Line Chickens Cleavage Coding Collaboration Cytoskeleton Cytoskeleton - virology Epitope Mapping Fibroblasts - virology Gangrene Gene expression Gene Expression Regulation, Viral Genomes HEK293 Cells Humans Infections Infectious bursal disease Infectious bursal disease virus - genetics Infectious bursal disease virus - metabolism Infectious diseases Isoelectric Point Isoelectric points Kinases Laboratories Mass spectrometry Mass spectroscopy Medical diagnosis Molecular chains Molecular Sequence Data Monoclonal antibodies Mutagenesis, Site-Directed Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Precursors Proteases Protein Precursors - genetics Protein Precursors - metabolism Proteins Proteolysis RNA polymerase Serine Veterinary colleges Veterinary medicine Viral infections Viral Structural Proteins - genetics Viral Structural Proteins - metabolism Virology Viruses VP3 protein VP4 protein West Nile virus
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