Consequences of low dose ionizing radiation exposure on the hippocampal microenvironment

The response of the brain to irradiation is complex, involving a multitude of stress inducible pathways that regulate neurotransmission within a dynamic microenvironment. While significant past work has detailed the consequences of CNS radiotherapy following relatively high doses (≥ 45 Gy), few stud...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0128316-e0128316
Hauptverfasser:	Acharya, Munjal M, Patel, Neal H, Craver, Brianna M, Tran, Katherine K, Giedzinski, Erich, Tseng, Bertrand P, Parihar, Vipan K, Limoli, Charles L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animal cognition Animals BASIC BIOLOGICAL SCIENCES Biomarkers - metabolism Brain CC chemokine receptors CCR2 protein Cell cycle Cell Proliferation - radiation effects Cell survival Cell Survival - radiation effects Cellular Microenvironment - radiation effects Central nervous system Cerebral Cortex - metabolism Cerebral Cortex - radiation effects Charged particles Chemokines Dentate Gyrus - cytology Dose-Response Relationship, Radiation Exposure Gene expression Gene Expression Regulation - radiation effects Genotypes Hippocampus Hippocampus - cytology Hippocampus - radiation effects Inflammation Inflammation Mediators - metabolism Ionizing radiation Irradiation Laboratory animals Learning Memory Metabolism Mice Mice, Inbred C57BL Mice, Knockout Microglia Microglia - metabolism Microglia - radiation effects Monocyte chemoattractant protein 1 Nervous system Neurogenesis Neurogenesis - radiation effects Neurons Neuroprotection Neurotransmission Oncology Oxidative stress Phenotypes Progenitor cells Radiation Radiation dosage Radiation effects Radiation Exposure Radiation therapy Radiation, Ionizing RADIOLOGY AND NUCLEAR MEDICINE Receptors, CCR2 - deficiency Receptors, CCR2 - metabolism Rodents Science & Technology - Other Topics Signaling Trends
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