The suppression of maternal-fetal leukemia inhibitory factor signal relay pathway by maternal immune activation impairs brain development in mice

Recent studies in rodents suggest that maternal immune activation (MIA) by viral infection is associated with schizophrenia and autism in offspring. Although maternal IL-6 is though t to be a possible mediator relating MIA induced these neuropsychiatric disorders, the mechanism remains to be elucida...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0129011-e0129011
Hauptverfasser:	Tsukada, Tsuyoshi, Simamura, Eriko, Shimada, Hiroki, Arai, Takuma, Higashi, Nobuaki, Akai, Takuya, Iizuka, Hideaki, Hatta, Toshihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adrenocorticotropic hormone Adrenocorticotropic Hormone - metabolism Animals Autism Brain Brain - embryology Brain - metabolism Cell division Cerebrospinal fluid Cerebrum Corticotropin Cytokine Receptor gp130 - metabolism Cytokines Disease susceptibility Embryos Female Fetus - metabolism Fetuses Fluids Gene expression Gene Expression Regulation Health aspects Immune response Immunity Infection Infections Interleukin 6 Interleukin-6 - metabolism Janus Kinases - metabolism Laboratory animals Leukemia Leukemia inhibitory factor Leukemia Inhibitory Factor - metabolism Mental disorders Mice, Inbred C57BL Neurogenesis Neurosurgery Offspring Placenta Placenta - metabolism Pregnancy Relay Rodents Schizophrenia Signal Transduction Signaling SOCS-3 protein STAT3 Transcription Factor - metabolism Viral infections
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