An ex vivo model for studying hepatic schistosomiasis and the effect of released protein from dying eggs

We report the use of an ex vivo precision cut liver slice (PCLS) mouse model for studying hepatic schistosomiasis. In this system, liver tissue is unfixed, unfrozen, and alive for maintenance in culture and subsequent molecular analysis. Using thick naive mouse liver tissue and sterile culture condi...

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Veröffentlicht in:	PLoS neglected tropical diseases 2015-05, Vol.9 (5), p.e0003760
Hauptverfasser:	Gobert, Geoffrey N, Nawaratna, Sujeevi K, Harvie, Marina, Ramm, Grant A, McManus, Donald P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Protozoan - immunology CD40 Antigens - immunology Chemokine CCL4 - immunology Chemokine CXCL5 - immunology Chemokines Collagen Disease Models, Animal Eggs Eggs (Biology) Enzymes Experiments Gene Expression Health aspects Infections Inflammation - immunology Inflammation - parasitology Interleukin-1alpha - immunology Interleukin-1beta - immunology Interleukin-6 - immunology Liver Liver - parasitology Liver Diseases, Parasitic - immunology Liver Diseases, Parasitic - parasitology Macrophage Colony-Stimulating Factor - immunology Medical research Mice Ovum - immunology Parasites Pathology Proteins Schistosomiasis Schistosomiasis - immunology Schistosomiasis - parasitology Schistosomiasis - pathology Studies Tissue Inhibitor of Metalloproteinase-1 - biosynthesis Tropical diseases
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