Economic and disease burden of dengue in Mexico
Dengue imposes a substantial economic and disease burden in most tropical and subtropical countries. Dengue incidence and severity have dramatically increased in Mexico during the past decades. Having objective and comparable estimates of the economic burden of dengue is essential to inform health p...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2015-03, Vol.9 (3), p.e0003547-e0003547 |
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| creator | Undurraga, Eduardo A Betancourt-Cravioto, Miguel Ramos-Castañeda, José Martínez-Vega, Ruth Méndez-Galván, Jorge Gubler, Duane J Guzmán, María G Halstead, Scott B Harris, Eva Kuri-Morales, Pablo Tapia-Conyer, Roberto Shepard, Donald S |
| description | Dengue imposes a substantial economic and disease burden in most tropical and subtropical countries. Dengue incidence and severity have dramatically increased in Mexico during the past decades. Having objective and comparable estimates of the economic burden of dengue is essential to inform health policy, increase disease awareness, and assess the impact of dengue prevention and control technologies.
We estimated the annual economic and disease burden of dengue in Mexico for the years 2010-2011. We merged multiple data sources, including a prospective cohort study; patient interviews and macro-costing from major hospitals; surveillance, budget, and health data from the Ministry of Health; WHO cost estimates; and available literature. We conducted a probabilistic sensitivity analysis using Monte Carlo simulations to derive 95% certainty levels (CL) for our estimates. Results suggest that Mexico had about 139,000 (95%CL: 128,000-253,000) symptomatic and 119 (95%CL: 75-171) fatal dengue episodes annually on average (2010-2011), compared to an average of 30,941 symptomatic and 59 fatal dengue episodes reported. The annual cost, including surveillance and vector control, was US$170 (95%CL: 151-292) million, or $1.56 (95%CL: 1.38-2.68) per capita, comparable to other countries in the region. Of this, $87 (95%CL: 87-209) million or $0.80 per capita (95%CL: 0.62-1.12) corresponds to illness. Annual disease burden averaged 65 (95%CL: 36-99) disability-adjusted life years (DALYs) per million population. Inclusion of long-term sequelae, co-morbidities, impact on tourism, and health system disruption during outbreaks would further increase estimated economic and disease burden.
With this study, Mexico joins Panama, Puerto Rico, Nicaragua, and Thailand as the only countries or areas worldwide with comprehensive (illness and preventive) empirical estimates of dengue burden. Burden varies annually; during an outbreak, dengue burden may be significantly higher than that of the pre-vaccine level of rotavirus diarrhea. In sum, Mexico's potential economic benefits from dengue control would be substantial. |
| doi_str_mv | 10.1371/journal.pntd.0003547 |
| format | Article |
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We estimated the annual economic and disease burden of dengue in Mexico for the years 2010-2011. We merged multiple data sources, including a prospective cohort study; patient interviews and macro-costing from major hospitals; surveillance, budget, and health data from the Ministry of Health; WHO cost estimates; and available literature. We conducted a probabilistic sensitivity analysis using Monte Carlo simulations to derive 95% certainty levels (CL) for our estimates. Results suggest that Mexico had about 139,000 (95%CL: 128,000-253,000) symptomatic and 119 (95%CL: 75-171) fatal dengue episodes annually on average (2010-2011), compared to an average of 30,941 symptomatic and 59 fatal dengue episodes reported. The annual cost, including surveillance and vector control, was US$170 (95%CL: 151-292) million, or $1.56 (95%CL: 1.38-2.68) per capita, comparable to other countries in the region. Of this, $87 (95%CL: 87-209) million or $0.80 per capita (95%CL: 0.62-1.12) corresponds to illness. Annual disease burden averaged 65 (95%CL: 36-99) disability-adjusted life years (DALYs) per million population. Inclusion of long-term sequelae, co-morbidities, impact on tourism, and health system disruption during outbreaks would further increase estimated economic and disease burden.
With this study, Mexico joins Panama, Puerto Rico, Nicaragua, and Thailand as the only countries or areas worldwide with comprehensive (illness and preventive) empirical estimates of dengue burden. Burden varies annually; during an outbreak, dengue burden may be significantly higher than that of the pre-vaccine level of rotavirus diarrhea. In sum, Mexico's potential economic benefits from dengue control would be substantial.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0003547</identifier><identifier>PMID: 25786225</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Agreements ; Budgets ; Cohort Studies ; Cost estimates ; Cost of Illness ; Dengue - economics ; Dengue - epidemiology ; Dengue fever ; Distribution ; Economic aspects ; Health Policy - economics ; Health risk assessment ; Hospitals ; Humans ; Illnesses ; Incidence ; Male ; Mexico ; Mortality ; Nicaragua ; Panama ; Per capita ; Population ; Prospective Studies ; Puerto Rico ; Quality-Adjusted Life Years ; Studies ; Surveillance ; Thailand ; Tourism ; Vaccines</subject><ispartof>PLoS neglected tropical diseases, 2015-03, Vol.9 (3), p.e0003547-e0003547</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Undurraga et al 2015 Undurraga et al</rights><rights>2015 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Undurraga EA, Betancourt-Cravioto M, Ramos-Castañeda J, Martínez-Vega R, Méndez-Galván J, Gubler DJ, et al. (2015) Economic and Disease Burden of Dengue in Mexico. PLoS Negl Trop Dis 9(3): e0003547. doi:10.1371/journal.pntd.0003547</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c629t-fe71a30e2fe89ba00e37764cffa875b44231972cb0ec2a37cb7da86cfc2197cf3</citedby><cites>FETCH-LOGICAL-c629t-fe71a30e2fe89ba00e37764cffa875b44231972cb0ec2a37cb7da86cfc2197cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364886/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364886/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25786225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Carvalho, Marilia Sá</contributor><creatorcontrib>Undurraga, Eduardo A</creatorcontrib><creatorcontrib>Betancourt-Cravioto, Miguel</creatorcontrib><creatorcontrib>Ramos-Castañeda, José</creatorcontrib><creatorcontrib>Martínez-Vega, Ruth</creatorcontrib><creatorcontrib>Méndez-Galván, Jorge</creatorcontrib><creatorcontrib>Gubler, Duane J</creatorcontrib><creatorcontrib>Guzmán, María G</creatorcontrib><creatorcontrib>Halstead, Scott B</creatorcontrib><creatorcontrib>Harris, Eva</creatorcontrib><creatorcontrib>Kuri-Morales, Pablo</creatorcontrib><creatorcontrib>Tapia-Conyer, Roberto</creatorcontrib><creatorcontrib>Shepard, Donald S</creatorcontrib><title>Economic and disease burden of dengue in Mexico</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Dengue imposes a substantial economic and disease burden in most tropical and subtropical countries. Dengue incidence and severity have dramatically increased in Mexico during the past decades. Having objective and comparable estimates of the economic burden of dengue is essential to inform health policy, increase disease awareness, and assess the impact of dengue prevention and control technologies.
We estimated the annual economic and disease burden of dengue in Mexico for the years 2010-2011. We merged multiple data sources, including a prospective cohort study; patient interviews and macro-costing from major hospitals; surveillance, budget, and health data from the Ministry of Health; WHO cost estimates; and available literature. We conducted a probabilistic sensitivity analysis using Monte Carlo simulations to derive 95% certainty levels (CL) for our estimates. Results suggest that Mexico had about 139,000 (95%CL: 128,000-253,000) symptomatic and 119 (95%CL: 75-171) fatal dengue episodes annually on average (2010-2011), compared to an average of 30,941 symptomatic and 59 fatal dengue episodes reported. The annual cost, including surveillance and vector control, was US$170 (95%CL: 151-292) million, or $1.56 (95%CL: 1.38-2.68) per capita, comparable to other countries in the region. Of this, $87 (95%CL: 87-209) million or $0.80 per capita (95%CL: 0.62-1.12) corresponds to illness. Annual disease burden averaged 65 (95%CL: 36-99) disability-adjusted life years (DALYs) per million population. Inclusion of long-term sequelae, co-morbidities, impact on tourism, and health system disruption during outbreaks would further increase estimated economic and disease burden.
With this study, Mexico joins Panama, Puerto Rico, Nicaragua, and Thailand as the only countries or areas worldwide with comprehensive (illness and preventive) empirical estimates of dengue burden. Burden varies annually; during an outbreak, dengue burden may be significantly higher than that of the pre-vaccine level of rotavirus diarrhea. In sum, Mexico's potential economic benefits from dengue control would be substantial.</description><subject>Adult</subject><subject>Agreements</subject><subject>Budgets</subject><subject>Cohort Studies</subject><subject>Cost estimates</subject><subject>Cost of Illness</subject><subject>Dengue - economics</subject><subject>Dengue - epidemiology</subject><subject>Dengue fever</subject><subject>Distribution</subject><subject>Economic aspects</subject><subject>Health Policy - economics</subject><subject>Health risk assessment</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Incidence</subject><subject>Male</subject><subject>Mexico</subject><subject>Mortality</subject><subject>Nicaragua</subject><subject>Panama</subject><subject>Per capita</subject><subject>Population</subject><subject>Prospective Studies</subject><subject>Puerto Rico</subject><subject>Quality-Adjusted Life Years</subject><subject>Studies</subject><subject>Surveillance</subject><subject>Thailand</subject><subject>Tourism</subject><subject>Vaccines</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNkkuLFDEQxxtR3HX1G4g2COJlZvN-XBaWZdWFFS96DumkMpOhJxk73aLf3rQzu8yAB8mhQuVX_0o9muY1RktMJb7c5GlItl_u0uiXCCHKmXzSnGNN-YJIyp8e3c-aF6VsEOKaK_y8OSNcKkEIP28ub11OeRtda5NvfSxgC7TdNHhIbQ5tNasJ2pjaL_AruvyyeRZsX-DVwV403z_efrv5vLj_-unu5vp-4QTR4yKAxJYiIAGU7ixCQKUUzIVgleQdY4RiLYnrEDhiqXSd9FYJFxypfhfoRfN2r7vrczGHWovBQnFBpOC0End7wme7Mbshbu3w22QbzV9HHlbGDmN0PRikBUFYOS48Ytw61THCKVKdDtQTp6vW1SHb1G3BO0jjYPsT0dOXFNdmlX8aRgVTSlSBDweBIf-YoIxmG4uDvrcJ8jT_W1KqsVb4P1DBMZZazCW-26MrW6uIKeSa3M24uWZYaUWYVpVa_oOqx0Oda04QYvWfBLw_CliD7cd1yf00xpzKKcj2oBtyKQOEx45gZOYlfBiMmZfQHJawhr057uZj0MPW0T9P29cS</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Undurraga, Eduardo A</creator><creator>Betancourt-Cravioto, Miguel</creator><creator>Ramos-Castañeda, José</creator><creator>Martínez-Vega, Ruth</creator><creator>Méndez-Galván, Jorge</creator><creator>Gubler, Duane J</creator><creator>Guzmán, María G</creator><creator>Halstead, Scott B</creator><creator>Harris, Eva</creator><creator>Kuri-Morales, Pablo</creator><creator>Tapia-Conyer, Roberto</creator><creator>Shepard, Donald S</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150301</creationdate><title>Economic and disease burden of dengue in Mexico</title><author>Undurraga, Eduardo A ; Betancourt-Cravioto, Miguel ; Ramos-Castañeda, José ; Martínez-Vega, Ruth ; Méndez-Galván, Jorge ; Gubler, Duane J ; Guzmán, María G ; Halstead, Scott B ; Harris, Eva ; Kuri-Morales, Pablo ; Tapia-Conyer, Roberto ; Shepard, Donald S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c629t-fe71a30e2fe89ba00e37764cffa875b44231972cb0ec2a37cb7da86cfc2197cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Agreements</topic><topic>Budgets</topic><topic>Cohort Studies</topic><topic>Cost estimates</topic><topic>Cost of Illness</topic><topic>Dengue - economics</topic><topic>Dengue - epidemiology</topic><topic>Dengue fever</topic><topic>Distribution</topic><topic>Economic aspects</topic><topic>Health Policy - economics</topic><topic>Health risk assessment</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Incidence</topic><topic>Male</topic><topic>Mexico</topic><topic>Mortality</topic><topic>Nicaragua</topic><topic>Panama</topic><topic>Per capita</topic><topic>Population</topic><topic>Prospective Studies</topic><topic>Puerto Rico</topic><topic>Quality-Adjusted Life Years</topic><topic>Studies</topic><topic>Surveillance</topic><topic>Thailand</topic><topic>Tourism</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Undurraga, Eduardo A</creatorcontrib><creatorcontrib>Betancourt-Cravioto, Miguel</creatorcontrib><creatorcontrib>Ramos-Castañeda, José</creatorcontrib><creatorcontrib>Martínez-Vega, Ruth</creatorcontrib><creatorcontrib>Méndez-Galván, Jorge</creatorcontrib><creatorcontrib>Gubler, Duane J</creatorcontrib><creatorcontrib>Guzmán, María G</creatorcontrib><creatorcontrib>Halstead, Scott B</creatorcontrib><creatorcontrib>Harris, Eva</creatorcontrib><creatorcontrib>Kuri-Morales, Pablo</creatorcontrib><creatorcontrib>Tapia-Conyer, Roberto</creatorcontrib><creatorcontrib>Shepard, Donald S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Undurraga, Eduardo A</au><au>Betancourt-Cravioto, Miguel</au><au>Ramos-Castañeda, José</au><au>Martínez-Vega, Ruth</au><au>Méndez-Galván, Jorge</au><au>Gubler, Duane J</au><au>Guzmán, María G</au><au>Halstead, Scott B</au><au>Harris, Eva</au><au>Kuri-Morales, Pablo</au><au>Tapia-Conyer, Roberto</au><au>Shepard, Donald S</au><au>Carvalho, Marilia Sá</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Economic and disease burden of dengue in Mexico</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>9</volume><issue>3</issue><spage>e0003547</spage><epage>e0003547</epage><pages>e0003547-e0003547</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Dengue imposes a substantial economic and disease burden in most tropical and subtropical countries. Dengue incidence and severity have dramatically increased in Mexico during the past decades. Having objective and comparable estimates of the economic burden of dengue is essential to inform health policy, increase disease awareness, and assess the impact of dengue prevention and control technologies.
We estimated the annual economic and disease burden of dengue in Mexico for the years 2010-2011. We merged multiple data sources, including a prospective cohort study; patient interviews and macro-costing from major hospitals; surveillance, budget, and health data from the Ministry of Health; WHO cost estimates; and available literature. We conducted a probabilistic sensitivity analysis using Monte Carlo simulations to derive 95% certainty levels (CL) for our estimates. Results suggest that Mexico had about 139,000 (95%CL: 128,000-253,000) symptomatic and 119 (95%CL: 75-171) fatal dengue episodes annually on average (2010-2011), compared to an average of 30,941 symptomatic and 59 fatal dengue episodes reported. The annual cost, including surveillance and vector control, was US$170 (95%CL: 151-292) million, or $1.56 (95%CL: 1.38-2.68) per capita, comparable to other countries in the region. Of this, $87 (95%CL: 87-209) million or $0.80 per capita (95%CL: 0.62-1.12) corresponds to illness. Annual disease burden averaged 65 (95%CL: 36-99) disability-adjusted life years (DALYs) per million population. Inclusion of long-term sequelae, co-morbidities, impact on tourism, and health system disruption during outbreaks would further increase estimated economic and disease burden.
With this study, Mexico joins Panama, Puerto Rico, Nicaragua, and Thailand as the only countries or areas worldwide with comprehensive (illness and preventive) empirical estimates of dengue burden. Burden varies annually; during an outbreak, dengue burden may be significantly higher than that of the pre-vaccine level of rotavirus diarrhea. In sum, Mexico's potential economic benefits from dengue control would be substantial.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25786225</pmid><doi>10.1371/journal.pntd.0003547</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Agreements Budgets Cohort Studies Cost estimates Cost of Illness Dengue - economics Dengue - epidemiology Dengue fever Distribution Economic aspects Health Policy - economics Health risk assessment Hospitals Humans Illnesses Incidence Male Mexico Mortality Nicaragua Panama Per capita Population Prospective Studies Puerto Rico Quality-Adjusted Life Years Studies Surveillance Thailand Tourism Vaccines |
| title | Economic and disease burden of dengue in Mexico |
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