Species-specific antimonial sensitivity in Leishmania is driven by post-transcriptional regulation of AQP1

Leishmania is a digenetic protozoan parasite causing leishmaniasis in humans. The different clinical forms of leishmaniasis are caused by more than twenty species of Leishmania that are transmitted by nearly thirty species of phlebotomine sand flies. Pentavalent antimonials (such as Pentostam or Glu...

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Veröffentlicht in:	PLoS neglected tropical diseases 2015-02, Vol.9 (2), p.e0003500-e0003500
Hauptverfasser:	Mandal, Goutam, Mandal, Srotoswati, Sharma, Mansi, Charret, Karen Santos, Papadopoulou, Barbara, Bhattacharjee, Hiranmoy, Mukhopadhyay, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Antimony - chemistry Antimony - metabolism Antimony Sodium Gluconate - therapeutic use Antiprotozoal Agents - therapeutic use Aquaglyceroporins - metabolism Aquaporin 1 - genetics Cell adhesion & migration Cell Movement - genetics Colleges & universities Distribution Drug Resistance - genetics Drugs Experiments Gene Expression Regulation - genetics Genetic aspects Health aspects Humans Identification and classification Leishmania Leishmania - classification Leishmania - drug effects Leishmania - genetics Leishmaniasis Leishmaniasis, Cutaneous - drug therapy Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Visceral - drug therapy Leishmaniasis, Visceral - parasitology Mammals Meglumine - therapeutic use Meglumine Antimoniate MicroRNA Organometallic Compounds - therapeutic use Parasites Parasitic diseases Properties RNA, Messenger - genetics RNA, Protozoan - genetics Rodents
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