Golgi-located NTPDase1 of Leishmania major is required for lipophosphoglycan elongation and normal lesion development whereas secreted NTPDase2 is dispensable for virulence

Parasitic protozoa, such as Leishmania species, are thought to express a number of surface and secreted nucleoside triphosphate diphosphohydrolases (NTPDases) which hydrolyze a broad range of nucleoside tri- and diphosphates. However, the functional significance of NTPDases in parasite virulence is...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS neglected tropical diseases 2014-12, Vol.8 (12), p.e3402-e3402
Hauptverfasser:	Sansom, Fiona M, Ralton, Julie E, Sernee, M Fleur, Cohen, Alice M, Hooker, David J, Hartland, Elizabeth L, Naderer, Thomas, McConville, Malcolm J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - physiology Apyrase - genetics Apyrase - physiology Biological research Biology and Life Sciences Biology, Experimental Chromosomes Colleges & universities Complement System Proteins - immunology Disease transmission Enzymes Female Genes Genetic aspects Glycosphingolipids - metabolism Golgi Apparatus - enzymology Hydrolases Infections Leishmania Leishmania major Leishmania major - metabolism Leishmania major - pathogenicity Leishmaniasis, Cutaneous - etiology LPG Mammals Medicine and Health Sciences Mice Mice, Inbred BALB C Mutation Parasites Parasitic diseases Pathogenesis Polymerase chain reaction Properties Proteins Virulence
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!