Hepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with Benznidazole

Treatment of Chagas disease, caused by Trypanosoma cruzi, relies on nifurtimox and benznidazole (BZL), which present side effects in adult patients, and natural resistance in some parasite strains. Hydroxymethylnitrofurazone (NFOH) is a new drug candidate with demonstrated trypanocidal activity; how...

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Veröffentlicht in:	PLoS neglected tropical diseases 2014-10, Vol.8 (10), p.e3231
Hauptverfasser:	Davies, Carolina, Dey, Nilay, Negrette, Olga Sanchez, Parada, Luis Antonio, Basombrio, Miguel A, Garg, Nisha Jain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biology and Life Sciences Cardiomyopathy Care and treatment Cell Death - drug effects Cell Line, Tumor Chagas Disease - drug therapy Chagas' disease Chemical and Drug Induced Liver Injury Chronic illnesses DNA damage DNA Damage - drug effects Drug dosages Female Hep G2 Cells Humans Infections Lipids Liver - drug effects Liver - pathology Male Medicine and Health Sciences Mice Mitochondria - drug effects Nifurtimox - therapeutic use Nitrofurazone - adverse effects Nitrofurazone - analogs & derivatives Nitrofurazone - therapeutic use Nitroimidazoles - adverse effects Nitroimidazoles - therapeutic use Oxidative stress Parasites Protozoa Reactive Oxygen Species - metabolism Rodents Studies Toxicity Trypanocidal Agents - adverse effects Trypanocidal Agents - therapeutic use Trypanosoma cruzi - drug effects Tumor Necrosis Factor-alpha Tyrosine - analogs & derivatives
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