Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations
There have been several recent changes in the taxonomy of Sporothrix schenckii as well as new observations regarding the clinical aspects of sporotrichosis. In this study, we determined the identification of the Sporothrix species associated with both classic and unusual clinical aspects of sporotri...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2014-09, Vol.8 (9), p.e3094-e3094 |
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| creator | Almeida-Paes, Rodrigo de Oliveira, Manoel Marques Evangelista Freitas, Dayvison Francis Saraiva do Valle, Antônio Carlos Francesconi Zancopé-Oliveira, Rosely Maria Gutierrez-Galhardo, Maria Clara |
| description | There have been several recent changes in the taxonomy of Sporothrix schenckii as well as new observations regarding the clinical aspects of sporotrichosis. In this study, we determined the identification of the Sporothrix species associated with both classic and unusual clinical aspects of sporotrichosis observed in the endemic area of sporotrichosis in Rio de Janeiro, Brazil.
To verify whether S. brasiliensis is associated with clinical manifestations of sporotrichosis, a cross-sectional study was performed in which Sporothrix isolates from 50 patients with different clinical manifestations were analyzed and their isolates were studied by phenotypic and genotypic methods. Data from these patients revealed a distinct clinical picture and therapeutic response in infections caused by Sporothrix brasiliensis (n = 45) compared to patients with S. schenckii sensu stricto (n = 5). S. brasiliensis was associated with disseminated cutaneous infection without underlying disease, hypersensitivity reactions, and mucosal infection, whereas patients with S. schenckii presented with less severe and more often localized disease, similar to the majority of previously described sporotrichosis cases. Interestingly, S. brasiliensis-infected patients overall required shorter durations of itraconazole (median 16 weeks) compared to the individuals with S. schenckii (median 24 weeks).
These findings suggest that Sporothrix species are linked to different clinical manifestations of sporotrichosis and that S. brasiliensis is effectively treated with oral itraconazole. |
| doi_str_mv | 10.1371/journal.pntd.0003094 |
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To verify whether S. brasiliensis is associated with clinical manifestations of sporotrichosis, a cross-sectional study was performed in which Sporothrix isolates from 50 patients with different clinical manifestations were analyzed and their isolates were studied by phenotypic and genotypic methods. Data from these patients revealed a distinct clinical picture and therapeutic response in infections caused by Sporothrix brasiliensis (n = 45) compared to patients with S. schenckii sensu stricto (n = 5). S. brasiliensis was associated with disseminated cutaneous infection without underlying disease, hypersensitivity reactions, and mucosal infection, whereas patients with S. schenckii presented with less severe and more often localized disease, similar to the majority of previously described sporotrichosis cases. Interestingly, S. brasiliensis-infected patients overall required shorter durations of itraconazole (median 16 weeks) compared to the individuals with S. schenckii (median 24 weeks).
These findings suggest that Sporothrix species are linked to different clinical manifestations of sporotrichosis and that S. brasiliensis is effectively treated with oral itraconazole.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0003094</identifier><identifier>PMID: 25233227</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antifungal Agents - administration & dosage ; Antifungal Agents - therapeutic use ; Ascomycota ; Brazil - epidemiology ; Causes of ; Cross-Sectional Studies ; Deoxyribonucleic acid ; Distribution ; DNA ; Drug Administration Schedule ; Female ; Fungal infections ; Fungi ; Genotype ; Humans ; Identification and classification ; Itraconazole - administration & dosage ; Itraconazole - therapeutic use ; Laboratories ; Male ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Patients ; Species Specificity ; Sporothrix ; Sporothrix - classification ; Sporotrichosis ; Sporotrichosis - drug therapy ; Sporotrichosis - epidemiology ; Sporotrichosis - parasitology ; Sporotrichosis - pathology ; Studies ; Zoonoses</subject><ispartof>PLoS neglected tropical diseases, 2014-09, Vol.8 (9), p.e3094-e3094</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Almeida-Paes et al 2014 Almeida-Paes et al</rights><rights>2014 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Is Associated with Atypical Clinical Presentations. PLoS Negl Trop Dis 8(9): e3094. doi:10.1371/journal.pntd.0003094</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c629t-726b59f4ab76f610ce2fe0e7652c06847afba8a7bc63b2ed515ca35c02026c573</citedby><cites>FETCH-LOGICAL-c629t-726b59f4ab76f610ce2fe0e7652c06847afba8a7bc63b2ed515ca35c02026c573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169245/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169245/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25233227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Almeida-Paes, Rodrigo</creatorcontrib><creatorcontrib>de Oliveira, Manoel Marques Evangelista</creatorcontrib><creatorcontrib>Freitas, Dayvison Francis Saraiva</creatorcontrib><creatorcontrib>do Valle, Antônio Carlos Francesconi</creatorcontrib><creatorcontrib>Zancopé-Oliveira, Rosely Maria</creatorcontrib><creatorcontrib>Gutierrez-Galhardo, Maria Clara</creatorcontrib><title>Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>There have been several recent changes in the taxonomy of Sporothrix schenckii as well as new observations regarding the clinical aspects of sporotrichosis. In this study, we determined the identification of the Sporothrix species associated with both classic and unusual clinical aspects of sporotrichosis observed in the endemic area of sporotrichosis in Rio de Janeiro, Brazil.
To verify whether S. brasiliensis is associated with clinical manifestations of sporotrichosis, a cross-sectional study was performed in which Sporothrix isolates from 50 patients with different clinical manifestations were analyzed and their isolates were studied by phenotypic and genotypic methods. Data from these patients revealed a distinct clinical picture and therapeutic response in infections caused by Sporothrix brasiliensis (n = 45) compared to patients with S. schenckii sensu stricto (n = 5). S. brasiliensis was associated with disseminated cutaneous infection without underlying disease, hypersensitivity reactions, and mucosal infection, whereas patients with S. schenckii presented with less severe and more often localized disease, similar to the majority of previously described sporotrichosis cases. Interestingly, S. brasiliensis-infected patients overall required shorter durations of itraconazole (median 16 weeks) compared to the individuals with S. schenckii (median 24 weeks).
These findings suggest that Sporothrix species are linked to different clinical manifestations of sporotrichosis and that S. brasiliensis is effectively treated with oral itraconazole.</description><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Ascomycota</subject><subject>Brazil - epidemiology</subject><subject>Causes of</subject><subject>Cross-Sectional Studies</subject><subject>Deoxyribonucleic acid</subject><subject>Distribution</subject><subject>DNA</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Fungi</subject><subject>Genotype</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Itraconazole - administration & dosage</subject><subject>Itraconazole - therapeutic use</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Medicine, Experimental</subject><subject>Patients</subject><subject>Species Specificity</subject><subject>Sporothrix</subject><subject>Sporothrix - classification</subject><subject>Sporotrichosis</subject><subject>Sporotrichosis - drug therapy</subject><subject>Sporotrichosis - epidemiology</subject><subject>Sporotrichosis - parasitology</subject><subject>Sporotrichosis - pathology</subject><subject>Studies</subject><subject>Zoonoses</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqFkl2L1DAUhoso7rr6D0QDgnjhjPlo0sYLYV38WFkQ_LgOp2k6zZBpapKq6683nZldZkCQXCQkz_smOectiscELwmryKu1n8IAbjkOqV1ijBmW5Z3ilEjGF7Ri_O7B-qR4EOMaYy55Te4XJ5RTxiitTov0dfTBp2B176ONyA7oi_WoNegTDMYG_xK9DfDHutdoR_bB_kZNgGidNcNWEhHE6LWFZFr0y6YeQboerQaHtLPDdjEGE82QIFk_xIfFvQ5cNI_281nx_f27bxcfF1efP1xenF8ttKAyLSoqGi67EppKdIJgbWhnsKkEpxqLuqyga6CGqtGCNdS0nHANjGtMMRWaV-yseLrzHZ2Pal-wqIioOaeyonUmLndE62GtxmA3EK6VB6u2Gz6sFIRktTPKdJIRjRtWClmKlgFwQakpMZgW03b2erO_bWo2ptX5uwHckenxyWB7tfI_VUmEpCXPBi_2BsH_mExMamOjNs7lTvhpfjelglBZkv-jXDBZZ5Jm9NkOXUH-hR263G3QM67OWS05ycmZH7_8B5VHazZW-8F0Nu8fCZ4fCHoDLvXRu2nb4GOw3IE6-BiD6W4rQrCak3zTGDUnWe2TnGVPDqt5K7qJLvsLNRHxzg</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Almeida-Paes, Rodrigo</creator><creator>de Oliveira, Manoel Marques Evangelista</creator><creator>Freitas, Dayvison Francis Saraiva</creator><creator>do Valle, Antônio Carlos Francesconi</creator><creator>Zancopé-Oliveira, Rosely Maria</creator><creator>Gutierrez-Galhardo, Maria Clara</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>M7N</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140901</creationdate><title>Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations</title><author>Almeida-Paes, Rodrigo ; 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In this study, we determined the identification of the Sporothrix species associated with both classic and unusual clinical aspects of sporotrichosis observed in the endemic area of sporotrichosis in Rio de Janeiro, Brazil.
To verify whether S. brasiliensis is associated with clinical manifestations of sporotrichosis, a cross-sectional study was performed in which Sporothrix isolates from 50 patients with different clinical manifestations were analyzed and their isolates were studied by phenotypic and genotypic methods. Data from these patients revealed a distinct clinical picture and therapeutic response in infections caused by Sporothrix brasiliensis (n = 45) compared to patients with S. schenckii sensu stricto (n = 5). S. brasiliensis was associated with disseminated cutaneous infection without underlying disease, hypersensitivity reactions, and mucosal infection, whereas patients with S. schenckii presented with less severe and more often localized disease, similar to the majority of previously described sporotrichosis cases. Interestingly, S. brasiliensis-infected patients overall required shorter durations of itraconazole (median 16 weeks) compared to the individuals with S. schenckii (median 24 weeks).
These findings suggest that Sporothrix species are linked to different clinical manifestations of sporotrichosis and that S. brasiliensis is effectively treated with oral itraconazole.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25233227</pmid><doi>10.1371/journal.pntd.0003094</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Public Library of Science (PLoS) |
| subjects | Antifungal Agents - administration & dosage Antifungal Agents - therapeutic use Ascomycota Brazil - epidemiology Causes of Cross-Sectional Studies Deoxyribonucleic acid Distribution DNA Drug Administration Schedule Female Fungal infections Fungi Genotype Humans Identification and classification Itraconazole - administration & dosage Itraconazole - therapeutic use Laboratories Male Medical research Medicine and Health Sciences Medicine, Experimental Patients Species Specificity Sporothrix Sporothrix - classification Sporotrichosis Sporotrichosis - drug therapy Sporotrichosis - epidemiology Sporotrichosis - parasitology Sporotrichosis - pathology Studies Zoonoses |
| title | Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations |
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