Eradication of yaws: historical efforts and achieving WHO's 2020 target
Yaws, one of the 17 neglected tropical diseases (NTDs), is targeted for eradication by 2020 in resolution WHA66.12 of the World Health Assembly (2013) and the WHO roadmap on NTDs (2012). The disease frequently affects children who live in poor socioeconomic conditions. Between 1952 and 1964, WHO and...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2014-09, Vol.8 (9), p.e3016-e3016 |
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| container_title | PLoS neglected tropical diseases |
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| creator | Asiedu, Kingsley Fitzpatrick, Christopher Jannin, Jean |
| description | Yaws, one of the 17 neglected tropical diseases (NTDs), is targeted for eradication by 2020 in resolution WHA66.12 of the World Health Assembly (2013) and the WHO roadmap on NTDs (2012). The disease frequently affects children who live in poor socioeconomic conditions. Between 1952 and 1964, WHO and the United Nations Children's Fund (UNICEF) led a global eradication campaign using injectable benzathine penicillin. Recent developments using a single dose of oral azithromycin have renewed optimism that eradication can be achieved through a comprehensive large-scale treatment strategy. We review historical efforts to eradicate yaws and argue that this goal is now technically feasible using new tools and with the favorable environment for control of NTDs. We also summarize the work of WHO's Department of Control of Neglected Tropical Diseases in leading the renewed eradication initiative and call on the international community to support efforts to achieve the 2020 eradication goal. The critical factor remains access to azithromycin. Excluding medicines, the financial cost of yaws eradication could be as little as US$ 100 million.
The development of new tools has renewed interest in eradication of yaws; with modest support, the WHO eradication target of 2020 can be achieved. |
| doi_str_mv | 10.1371/journal.pntd.0003016 |
| format | Article |
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The development of new tools has renewed interest in eradication of yaws; with modest support, the WHO eradication target of 2020 can be achieved.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Bacterial infections</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease Eradication</subject><subject>Global Health</subject><subject>Health facilities</subject><subject>Health promotion</subject><subject>History, 20th Century</subject><subject>History, 21st Century</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Neglected Diseases - drug therapy</subject><subject>Neglected Diseases - history</subject><subject>Neglected Diseases - prevention & control</subject><subject>Prevention</subject><subject>Review</subject><subject>Skin</subject><subject>Socioeconomic factors</subject><subject>Success</subject><subject>Tropical diseases</subject><subject>Yaws</subject><subject>Yaws - drug therapy</subject><subject>Yaws - epidemiology</subject><subject>Yaws - history</subject><subject>Yaws - prevention & control</subject><subject>Young Adult</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNkstu1DAUhiMEomXgDRBEQipsZji-xTYLpKoqbaVK3YBYWrbjZDzKxIPtFPXtmzBpNbNjZev4O_-5-C-K9whWiHD0dROG2OtutetzvQIAAqh6UZwiSdgSc8JeHtxPijcpbQCYZAK9Lk4ww4wSjk-Lq8uoa2919qEvQ1M-6L_pW7n2KYc4hrvSNU2IOZW6r0tt197d-74tf1_ffU4lBgxl1rF1-W3xqtFdcu_mc1H8-nH58-J6eXt3dXNxfru0TEJecsAGMwGOM44QA2LBCt1UFDUYATfISEON0dwaZ6mopKDUgMDWcYSdsWRRfNzr7rqQ1LyDpFAlGMOykmgkbvZEHfRG7aLf6viggvbqXyDEVumYve2cqoHoCgGuGbOUWCukc5RaWRkAYw2MWt_naoPZutq6PkfdHYkev_R-rdpwryjinI-bXxRfZoEY_gwuZbX1ybqu070Lw9Q3xkyOXZP_RJkgk-qnPdrqcQrfN2EsbidcnRMhGRrNQEfq7IBaO93ldQrdMH11OgbpHrQxpBRd8zwgAjV57WnPavKamr02pn04XM5z0pO5yCOsTc6v</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Asiedu, Kingsley</creator><creator>Fitzpatrick, Christopher</creator><creator>Jannin, Jean</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140901</creationdate><title>Eradication of yaws: historical efforts and achieving WHO's 2020 target</title><author>Asiedu, Kingsley ; Fitzpatrick, Christopher ; Jannin, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-702b2580e75711503c0c8af641f2107b1b9b4bba7cbec4869844b082ce712ebc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Bacterial infections</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease Eradication</topic><topic>Global Health</topic><topic>Health facilities</topic><topic>Health promotion</topic><topic>History, 20th Century</topic><topic>History, 21st Century</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Neglected Diseases - drug therapy</topic><topic>Neglected Diseases - history</topic><topic>Neglected Diseases - prevention & control</topic><topic>Prevention</topic><topic>Review</topic><topic>Skin</topic><topic>Socioeconomic factors</topic><topic>Success</topic><topic>Tropical diseases</topic><topic>Yaws</topic><topic>Yaws - drug therapy</topic><topic>Yaws - epidemiology</topic><topic>Yaws - history</topic><topic>Yaws - prevention & control</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asiedu, Kingsley</creatorcontrib><creatorcontrib>Fitzpatrick, Christopher</creatorcontrib><creatorcontrib>Jannin, Jean</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asiedu, Kingsley</au><au>Fitzpatrick, Christopher</au><au>Jannin, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eradication of yaws: historical efforts and achieving WHO's 2020 target</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>8</volume><issue>9</issue><spage>e3016</spage><epage>e3016</epage><pages>e3016-e3016</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Yaws, one of the 17 neglected tropical diseases (NTDs), is targeted for eradication by 2020 in resolution WHA66.12 of the World Health Assembly (2013) and the WHO roadmap on NTDs (2012). The disease frequently affects children who live in poor socioeconomic conditions. Between 1952 and 1964, WHO and the United Nations Children's Fund (UNICEF) led a global eradication campaign using injectable benzathine penicillin. Recent developments using a single dose of oral azithromycin have renewed optimism that eradication can be achieved through a comprehensive large-scale treatment strategy. We review historical efforts to eradicate yaws and argue that this goal is now technically feasible using new tools and with the favorable environment for control of NTDs. We also summarize the work of WHO's Department of Control of Neglected Tropical Diseases in leading the renewed eradication initiative and call on the international community to support efforts to achieve the 2020 eradication goal. The critical factor remains access to azithromycin. Excluding medicines, the financial cost of yaws eradication could be as little as US$ 100 million.
The development of new tools has renewed interest in eradication of yaws; with modest support, the WHO eradication target of 2020 can be achieved.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25254372</pmid><doi>10.1371/journal.pntd.0003016</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Anti-Bacterial Agents - administration & dosage Bacterial infections Child Child, Preschool Disease Eradication Global Health Health facilities Health promotion History, 20th Century History, 21st Century Humans Infant Infant, Newborn Infectious diseases Medicine and Health Sciences Methods Neglected Diseases - drug therapy Neglected Diseases - history Neglected Diseases - prevention & control Prevention Review Skin Socioeconomic factors Success Tropical diseases Yaws Yaws - drug therapy Yaws - epidemiology Yaws - history Yaws - prevention & control Young Adult |
| title | Eradication of yaws: historical efforts and achieving WHO's 2020 target |
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