Ultra-sensitive detection of Plasmodium falciparum by amplification of multi-copy subtelomeric targets

Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be identified by surveillance with molecular methods, yet these infections also contribute to onward transmission...

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Veröffentlicht in:	PLoS medicine 2015-03, Vol.12 (3), p.e1001788-e1001788
Hauptverfasser:	Hofmann, Natalie, Mwingira, Felista, Shekalaghe, Seif, Robinson, Leanne J, Mueller, Ivo, Felger, Ingrid
Format:	Artikel
Sprache:	eng
Schlagworte:	Control Cross-Sectional Studies Deoxyribonucleic acid Diagnosis Diagnòstic DNA DNA, Protozoan - blood Epidemiologia Epidemiology Genetic testing Genomes Health aspects Humans Identification and classification Infections Light Malaria Malaria, Falciparum - diagnosis Malaria, Falciparum - epidemiology Malaria, Falciparum - parasitology Malaria, Falciparum - transmission Malària Methods Microscopy Molecular Diagnostic Techniques - methods Molecular Epidemiology Mosquitoes Nucleic Acid Amplification Techniques - methods Parasites Plasmodium falciparum Plasmodium falciparum - genetics Polymerase chain reaction Population Prevalence Reacció en cadena de la polimerasa Real-Time Polymerase Chain Reaction Repetitive Sequences, Nucleic Acid - genetics RNA, Ribosomal, 18S - genetics Studies Surveillance Tanzania - epidemiology Telomere Vector control
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