A ribonucleoprotein complex protects the interleukin-6 mRNA from degradation by distinct herpesviral endonucleases

During lytic Kaposi's sarcoma-associated herpesvirus (KSHV) infection, the viral endonuclease SOX promotes widespread degradation of cytoplasmic messenger RNA (mRNA). However, select mRNAs escape SOX-induced cleavage and remain robustly expressed. Prominent among these is interleukin-6 (IL-6),...

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Veröffentlicht in:	PLoS pathogens 2015-05, Vol.11 (5), p.e1004899-e1004899
Hauptverfasser:	Muller, Mandy, Hutin, Stephanie, Marigold, Oliver, Li, Kathy H, Burlingame, Al, Glaunsinger, Britt A
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions B-Lymphocytes - metabolism B-Lymphocytes - pathology B-Lymphocytes - virology Cell Line, Transformed Cytokines Cytoplasm Endonucleases - metabolism Gene expression Genes, Reporter Genetic aspects Half-Life Health aspects HEK293 Cells Herpesviridae Infections - metabolism Herpesviridae Infections - pathology Herpesviridae Infections - virology Herpesvirus 8, Human - enzymology Herpesviruses Host-virus relationships Humans Hydrolysis Infections Interleukin-6 - genetics Interleukin-6 - metabolism Interleukins Kaposis sarcoma Mass spectrometry Medical research Messenger RNA Nucleolin Pathogenesis Phosphoproteins - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - metabolism Protein expression Protein Transport Recombinant Fusion Proteins - metabolism Response Elements Ribonucleoproteins Ribonucleoproteins - genetics Ribonucleoproteins - metabolism RNA - metabolism RNA Interference RNA Stability RNA, Messenger - metabolism RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Scientific imaging Software Viral infections Viral Proteins - metabolism
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