The immune adaptor ADAP regulates reciprocal TGF-[beta]1-integrin crosstalk to protect from influenza virus infection

Highly pathogenic avian influenza virus (HPAI, such as H5N1) infection causes severe cytokine storm and fatal respiratory immunopathogenesis in human and animal. Although TGFp1 and the integrin CD103 in [CD8.sup.+] T cells play protective roles in H5N1 virus infection, it is not fully understood whi...

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Veröffentlicht in:	PLoS pathogens 2015-04, Vol.11 (4)
Hauptverfasser:	Li, Chunyang, Jiao, Shaozhuo, Wang, Guojun, Gao, Yunzhen, Liu, Chang, He, Xijun, Zhang, Chi, Xiao, Jun, Li, Weiyun, Zhang, Guoquan, Wei, Bin, Chen, Hualan, Wang, Hongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Chemokines Deaths Disease Experiments Genetic aspects Health aspects Host-virus relationships Infections Influenza Integrins Lungs Lymphocytes Mortality Mutation Pandemics Prevention Public health Rodents Swine flu Transforming growth factors
Online-Zugang:	Volltext
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