Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection

Chronic infections are characterized by the inability to eliminate the persisting pathogen and often associated with functional impairment of virus-specific T-cell responses. Costimulation through Glucocorticoid-induced TNFR-related protein (GITR) can increase survival and function of effector T cel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS pathogens 2015-03, Vol.11 (3), p.e1004675-e1004675
Hauptverfasser:	Pascutti, Maria Fernanda, Geerman, Sulima, Slot, Edith, van Gisbergen, Klaas P J M, Boon, Louis, Arens, Ramon, van Lier, Rene A W, Wolkers, Monika C, Nolte, Martijn A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens CD40 Ligand - genetics CD40 Ligand - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Chronic Disease Glucocorticoid-Induced TNFR-Related Protein - genetics Glucocorticoid-Induced TNFR-Related Protein - immunology Hepatitis Immune system Immunity, Cellular Interferon-gamma - genetics Interferon-gamma - immunology Interleukin-2 - genetics Interleukin-2 - immunology Lymphocytic Choriomeningitis - genetics Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - pathology Lymphocytic choriomeningitis virus - immunology Mice Mice, Transgenic T cell receptors T-Box Domain Proteins - genetics T-Box Domain Proteins - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - pathology Viral infections
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!