Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells

Altered cell metabolism is inherently connected with pathological conditions including cancer and viral infections. Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS). KS tumour cells display features of lymphatic endothelial differentiation an...

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Veröffentlicht in:	PLoS pathogens 2014-09, Vol.10 (9), p.e1004400-e1004400
Hauptverfasser:	Yogev, Ohad, Lagos, Dimitris, Enver, Tariq, Boshoff, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobiosis Algorithms Biology and life sciences Biosynthesis Blotting, Western Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Neoplasms - virology Cancer Cell metabolism Cell Proliferation Endothelial Cells - metabolism Endothelial Cells - pathology Endothelial Cells - virology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - virology Energy Metabolism Experiments Gene Expression Regulation, Viral Genes Genetic aspects Genetic research Glucose - metabolism Herpesvirus 8, Human - physiology Humans Kaposi's sarcoma Kaposis sarcoma Lactic Acid - metabolism Medical research Metabolism MicroRNA MicroRNAs MicroRNAs - genetics Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondria - virology Mitochondrial DNA Osteosarcoma - metabolism Osteosarcoma - pathology Osteosarcoma - virology Oxygen Consumption Protein expression Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Sarcoma, Kaposi - metabolism Sarcoma, Kaposi - pathology Sarcoma, Kaposi - virology Tumor Cells, Cultured Viral infections Virion - metabolism Virus Latency Viruses
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