Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program

An overwhelming neutrophil-driven response causes both acute symptoms and the lasting sequelae that result from infection with Neisseria gonorrhoeae. Neutrophils undergo an aggressive opsonin-independent response to N. gonorrhoeae, driven by the innate decoy receptor CEACAM3. CEACAM3 is exclusively...

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Veröffentlicht in:	PLoS pathogens 2014-09, Vol.10 (9), p.e1004341-e1004341
Hauptverfasser:	Sintsova, Anna, Sarantis, Helen, Islam, Epshita A, Sun, Chun Xiang, Amin, Mohsen, Chan, Carlos H F, Stanners, Clifford P, Glogauer, Michael, Gray-Owen, Scott D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Bacteria Bacterial Adhesion Biology and Life Sciences Biomarkers - metabolism Carcinoembryonic Antigen - genetics Carcinoembryonic Antigen - metabolism Cytokines Cytokines - metabolism Diagnosis Drug therapy Enzyme-Linked Immunosorbent Assay Gene Expression Profiling Gonorrhea Gonorrhea - immunology Gonorrhea - metabolism Gonorrhea - microbiology Humans Infections Inflammation - etiology Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Intracellular Signaling Peptides and Proteins - metabolism Medicine and Health Sciences Mice Mice, Transgenic Microscopy Neisseria gonorrhoeae Neisseria gonorrhoeae - immunology Neisseria gonorrhoeae - pathogenicity Neutrophils Neutrophils - immunology Neutrophils - microbiology Oligonucleotide Array Sequence Analysis Oxidative Stress Phagocytosis - physiology Physiological aspects Protein-Tyrosine Kinases - metabolism Risk factors Rodents Sexually transmitted diseases Signal Transduction STD Syk Kinase
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