Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity

Etiological agents of acute, persistent, or relapsing clinical infections are often refractory to antibiotics due to multidrug resistance and/or antibiotic tolerance. Pseudomonas aeruginosa is an opportunistic Gram-negative bacterial pathogen that causes recalcitrant and severe acute chronic and per...

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Veröffentlicht in:	PLoS pathogens 2014-08, Vol.10 (8), p.e1004321-e1004321
Hauptverfasser:	Starkey, Melissa, Lepine, Francois, Maura, Damien, Bandyopadhaya, Arunava, Lesic, Biljana, He, Jianxin, Kitao, Tomoe, Righi, Valeria, Milot, Sylvain, Tzika, Aria, Rahme, Laurence
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antibiotics Bacterial infections Bacteriology Biology and Life Sciences Chromatin Immunoprecipitation Communications systems Data processing Disease Models, Animal Drug Discovery Drug resistance Drug Resistance, Bacterial - drug effects Drug Resistance, Multiple - drug effects Experiments Health aspects Infections Life Sciences Medicine and Health Sciences Mice Microbiology and Parasitology Molecular weight Pseudomonas aeruginosa - drug effects Pseudomonas Infections - microbiology Quorum sensing Quorum Sensing - physiology Virulence (Microbiology) Virulence - drug effects
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