Distal spike initiation zone location estimation by morphological simulation of ionic current filtering demonstrated in a novel model of an identified Drosophila motoneuron

Studying ion channel currents generated distally from the recording site is difficult because of artifacts caused by poor space clamp and membrane filtering. A computational model can quantify artifact parameters for correction by simulating the currents only if their exact anatomical location is kn...

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Veröffentlicht in:	PLoS computational biology 2015-05, Vol.11 (5), p.e1004189-e1004189
Hauptverfasser:	Günay, Cengiz, Sieling, Fred H, Dharmar, Logesh, Lin, Wei-Hsiang, Wolfram, Verena, Marley, Richard, Baines, Richard A, Prinz, Astrid A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Biophysical Phenomena Biophysics Computational Biology Computer Simulation Drosophila Drosophila melanogaster - cytology Drosophila melanogaster - physiology Electrophysiological Phenomena Experiments Insects Ion Channels - metabolism Models, Neurological Morphology Motor neurons Motor Neurons - physiology Motor Neurons - ultrastructure Neural circuitry Neurons Patch-Clamp Techniques Physiological aspects Physiology Simulation
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