MCL-1, BCL-XL and MITF Are Diversely Employed in Adaptive Response of Melanoma Cells to Changes in Microenvironment

Melanoma cells can switch their phenotypes in response to microenvironmental insults. Heterogeneous melanoma populations characterized by long-term growth and a high self-renewal capacity can be obtained in vitro in EGF(+)bFGF(+) medium whilst invasive potential of melanoma cells is increased in ser...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0128796-e0128796
Hauptverfasser:	Hartman, Mariusz L, Talar, Beata, Gajos-Michniewicz, Anna, Czyz, Malgorzata
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Apoptosis Bcl-2 protein Bcl-x protein bcl-X Protein - genetics bcl-X Protein - metabolism Cancer Cell death Cell Survival Drug resistance Epidermal growth factor Experiments Fibroblast growth factor 2 Fibroblasts Gene expression Gene Expression Regulation, Neoplastic Gene Silencing Growth conditions Humans Inhibition Insulin Mcl-1 protein Melanoma Melanoma - metabolism Melanoma - pathology Metabolism Microphthalmia-associated transcription factor Microphthalmia-Associated Transcription Factor - antagonists & inhibitors Microphthalmia-Associated Transcription Factor - genetics Microphthalmia-Associated Transcription Factor - metabolism Molecular biology Myeloid Cell Leukemia Sequence 1 Protein - genetics Myeloid Cell Leukemia Sequence 1 Protein - metabolism Populations Protein turnover Proteins RNA Stability RNA, Messenger - metabolism Signal Transduction Stability Survival Transcription Tumor Microenvironment
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!