Noise-driven causal inference in biomolecular networks

Single-cell RNA and protein concentrations dynamically fluctuate because of stochastic ("noisy") regulation. Consequently, biological signaling and genetic networks not only translate stimuli with functional response but also random fluctuations. Intuitively, this feature manifests as the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0125777-e0125777
Hauptverfasser:	Prill, Robert J, Vogel, Robert, Cecchi, Guillermo A, Altan-Bonnet, Grégoire, Stolovitzky, Gustavo
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biology Causality Causation Connectivity Covariance matrix E coli Escherichia coli Extracellular signal-regulated kinase Fluctuations Gene expression Immunohistochemistry Immunology Inference Kinases Lymphocytes Mammalian cells Mammals Methods Models, Biological Noise Noise propagation Phosphorylation Physics Protein expression Proteins Ribonucleic acid RNA Science Signaling Stochasticity Substrates Time series Variables
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!