Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization

Human antibody 10E8 targets the conserved membrane proximal external region (MPER) of envelope glycoprotein (Env) subunit gp41 and neutralizes HIV-1 with exceptional potency. Remarkably, HIV-1 containing mutations that reportedly knockout 10E8 binding to linear MPER peptides are partially neutralize...

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Veröffentlicht in:	PLoS pathogens 2014-07, Vol.10 (7), p.e1004271-e1004271
Hauptverfasser:	Kim, Arthur S, Leaman, Daniel P, Zwick, Michael B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Analysis Antibodies Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Biology and Life Sciences Gene mutations Health aspects HEK293 Cells HIV (Viruses) HIV Antibodies - chemistry HIV Antibodies - immunology HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - immunology HIV-1 - chemistry HIV-1 - immunology Humans Immunization Immunotherapy Ligands Medicine and Health Sciences Mutation Physiological aspects Plasmids Viral antibodies
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