A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. The molecular mechanisms used by this bacterium to create a pathogen-occupied vacuole remain largely unknown. Here, we conducted a visual screen on an arrayed library of C. burnetii NMII transposon insertio...

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Veröffentlicht in:	PLoS pathogens 2014-07, Vol.10 (7), p.e1004286-e1004286
Hauptverfasser:	Newton, Hayley J, Kohler, Lara J, McDonough, Justin A, Temoche-Diaz, Morayma, Crabill, Emerson, Hartland, Elizabeth L, Roy, Craig R
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Autophagy (Cytology) Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Secretion Systems - genetics Bacteriology Biology and Life Sciences Biosynthesis Coxiella burnetii - genetics Coxiella burnetii - metabolism Coxiella burnetii - pathogenicity Coxsackieviruses DNA Transposable Elements - genetics Experiments Fever Gene Expression Regulation, Bacterial Genotype & phenotype Health aspects HeLa Cells Host-Pathogen Interactions - genetics Humans Immunoblotting Infections Medicine and Health Sciences Metabolism Mutation Mutation - genetics Phagosomes - metabolism Physiological aspects Proteins Q Fever - metabolism Q Fever - microbiology Transfer RNA Vacuoles - metabolism Vacuoles - microbiology
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