HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after...
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| Veröffentlicht in: | PLoS pathogens 2014-07, Vol.10 (7), p.e1004146-e1004146 |
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| container_title | PLoS pathogens |
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| creator | Izquierdo-Useros, Nuria Lorizate, Maier McLaren, Paul J Telenti, Amalio Kräusslich, Hans-Georg Martinez-Picado, Javier |
| description | Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection. |
| doi_str_mv | 10.1371/journal.ppat.1004146 |
| format | Article |
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Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Izquierdo-Useros N, Lorizate M, McLaren PJ, Telenti A, Kräusslich H-G, Martinez-Picado J (2014) HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acquired immune deficiency syndrome AIDS Animals Bacteria Biology and life sciences Biomedical research Care and treatment Chemokines Dendritic cells Dendritic Cells - immunology Dendritic Cells - pathology Dendritic Cells - virology Distribution Gangliosides Genetic aspects Genomes Glycolipids - immunology Health aspects HIV HIV (Viruses) HIV Infections - immunology HIV Infections - pathology HIV-1 - immunology Human immunodeficiency virus Humans Immune system Infections Lectins Lymphocytes Medicine and Health Sciences Pathogenesis Physiological aspects Review Sialic Acid Binding Ig-like Lectin 1 - immunology T cells T-Lymphocytes - immunology T-Lymphocytes - pathology Viral infections Virus diseases Viruses |
| title | HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1 |
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