Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci

To functionally link coronary artery disease (CAD) causal genes identified by genome wide association studies (GWAS), and to investigate the cellular and molecular mechanisms of atherosclerosis, we have used chromatin immunoprecipitation sequencing (ChIP-Seq) with the CAD associated transcription fa...

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Veröffentlicht in:	PLoS genetics 2015-05, Vol.11 (5), p.e1005202-e1005202
Hauptverfasser:	Sazonova, Olga, Zhao, Yuqi, Nürnberg, Sylvia, Miller, Clint, Pjanic, Milos, Castano, Victor G, Kim, Juyong B, Salfati, Elias L, Kundaje, Anshul B, Bejerano, Gill, Assimes, Themistocles, Yang, Xia, Quertermous, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Atherosclerosis - genetics Atherosclerosis - pathology Basic Helix-Loop-Helix Transcription Factors - biosynthesis Basic Helix-Loop-Helix Transcription Factors - genetics Binding Sites Cardiovascular disease Coronary Artery Disease - genetics Coronary Artery Disease - pathology Coronary heart disease Coronary Vessels - cytology Coronary Vessels - metabolism DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Gene Expression Regulation Gene Regulatory Networks Genes Genetic aspects Genome-wide association studies Genome-Wide Association Study Genomes Health aspects Humans Hypotheses Linkage Disequilibrium Polymorphism, Single Nucleotide Quantitative Trait Loci - genetics Rodents Smooth muscle Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Transcription factors
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