Contribution of large region joint associations to complex traits genetics

A polygenic model of inheritance, whereby hundreds or thousands of weakly associated variants contribute to a trait's heritability, has been proposed to underlie the genetic architecture of complex traits. However, relatively few genetic variants have been positively identified so far and they...

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Veröffentlicht in:	PLoS genetics 2015-04, Vol.11 (4), p.e1005103-e1005103
Hauptverfasser:	Paré, Guillaume, Asma, Senay, Deng, Wei Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Body Mass Index C-Reactive Protein - genetics Cholesterol, LDL - genetics Chromosomes, Human - genetics Epigenetic inheritance Female Gene expression Genetic variation Genetics Genomes Genomics Humans Hypotheses Identification and classification Male Models, Genetic Phenotype Polymorphism, Single Nucleotide Quantitative Trait Loci Studies
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