Genome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeast

Topoisomerase 1 (Top1), a Type IB topoisomerase, functions to relieve transcription- and replication-associated torsional stress in DNA. We investigated the effects of Top1 on genome stability in Saccharomyces cerevisiae using two different assays. First, a sectoring assay that detects loss of heter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS genetics 2015-04, Vol.11 (4), p.e1005098-e1005098
Hauptverfasser:	Andersen, Sabrina L, Sloan, Roketa S, Petes, Thomas D, Jinks-Robertson, Sue
Format:	Artikel
Sprache:	eng
Schlagworte:	Camptothecin - pharmacology Chromosomes Cloning Crossing Over, Genetic Deoxyribonucleic acid DNA DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type I - metabolism Enzymes Experiments Genetic aspects Genome, Fungal Genome-wide association studies Genomes Genomic Instability Mutation Physiological aspects Ribosomal DNA RNA, Ribosomal - genetics Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Topoisomerase I Inhibitors - pharmacology Topoisomerases Yeast Yeasts (Fungi)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!