Selective and genetic constraints on pneumococcal serotype switching

Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into "serogroups" based on cross-reactivity with certain antibodies. Pneumococci can alter their serotype through recombinations a...

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Veröffentlicht in:	PLoS genetics 2015-03, Vol.11 (3), p.e1005095-e1005095
Hauptverfasser:	Croucher, Nicholas J, Kagedan, Lisa, Thompson, Claudette M, Parkhill, Julian, Bentley, Stephen D, Finkelstein, Jonathan A, Lipsitch, Marc, Hanage, William P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquisitions & mergers Antibodies - genetics Antibodies - immunology beta-Lactam Resistance - genetics Carbohydrates Gene expression Genetic aspects Genetic diversity Genome, Bacterial Genomes Genotype Homologous Recombination Host-bacteria relationships Humans Hypotheses Identification and classification Mathematical models Mortality Phylogeny Pneumococcal Infections - genetics Pneumococcal Infections - immunology Pneumococcal Infections - microbiology Pneumococcal Vaccines - genetics Pneumococcal Vaccines - immunology Proteins Sequence Alignment Serogroup Serotyping Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - genetics Streptococcus pneumoniae - immunology Streptococcus pneumoniae - pathogenicity Vaccines
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