Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes

The contribution of rare coding sequence variants to genetic susceptibility in complex disorders is an important but unresolved question. Most studies thus far have investigated a limited number of genes from regions which contain common disease associated variants. Here we investigate this in infla...

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Veröffentlicht in:	PLoS genetics 2015-02, Vol.11 (2), p.e1004955-e1004955
Hauptverfasser:	Prescott, Natalie J, Lehne, Benjamin, Stone, Kristina, Lee, James C, Taylor, Kirstin, Knight, Jo, Papouli, Efterpi, Mirza, Muddassar M, Simpson, Michael A, Spain, Sarah L, Lu, Grace, Fraternali, Franca, Bumpstead, Suzannah J, Gray, Emma, Amar, Ariella, Bye, Hannah, Green, Peter, Chung-Faye, Guy, Hayee, Bu'Hussain, Pollok, Richard, Satsangi, Jack, Parkes, Miles, Barrett, Jeffrey C, Mansfield, John C, Sanderson, Jeremy, Lewis, Cathryn M, Weale, Michael E, Schlitt, Thomas, Mathew, Christopher G
Format:	Artikel
Sprache:	eng
Schlagworte:	Butyrophilins Colitis, Ulcerative - genetics Colitis, Ulcerative - immunology Colitis, Ulcerative - pathology Crohn Disease - genetics Crohn Disease - immunology Crohn Disease - pathology DNA sequencing Genes Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genetic variation Genome-Wide Association Study High-Throughput Nucleotide Sequencing HLA Antigens - genetics Humans Identification and classification Inflammatory bowel disease Inflammatory bowel diseases Medical research Membrane Glycoproteins - genetics Methods Phenotype Polymorphism, Single Nucleotide Studies
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