Genome-wide analysis of DNA methylation dynamics during early human development

DNA methylation is globally reprogrammed during mammalian preimplantation development, which is critical for normal development. Recent reduced representation bisulfite sequencing (RRBS) studies suggest that the methylome dynamics are essentially conserved between human and mouse early embryos. RRBS...

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Veröffentlicht in:	PLoS genetics 2014-12, Vol.10 (12), p.e1004868-e1004868
Hauptverfasser:	Okae, Hiroaki, Chiba, Hatsune, Hiura, Hitoshi, Hamada, Hirotaka, Sato, Akiko, Utsunomiya, Takafumi, Kikuchi, Hiroyuki, Yoshida, Hiroaki, Tanaka, Atsushi, Suyama, Mikita, Arima, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biology and life sciences Biomedical research Blastocyst - physiology Blood CpG Islands Deoxyribonucleic acid DNA DNA Methylation DNA sequencing Embryo Culture Techniques Epigenetics Female Gene Expression Regulation, Developmental Genes Genetic aspects Genome-wide association studies Genome-Wide Association Study Genomes Genomic Imprinting Human development Humans Mammals Methylation Oocytes - physiology Placenta Satellites Sequence Analysis, DNA Sperm Studies Tandem Repeat Sequences
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