Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation

Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Aβ42) and tau levels are strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including amyloid plaques and neurodegeneration and have been successfully used as endophenotypes for genetic studies of AD....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS genetics 2014-10, Vol.10 (10), p.e1004758-e1004758
Hauptverfasser:	Kauwe, John S K, Bailey, Matthew H, Ridge, Perry G, Perry, Rachel, Wadsworth, Mark E, Hoyt, Kaitlyn L, Staley, Lyndsay A, Karch, Celeste M, Harari, Oscar, Cruchaga, Carlos, Ainscough, Benjamin J, Bales, Kelly, Pickering, Eve H, Bertelsen, Sarah, Fagan, Anne M, Holtzman, David M, Morris, John C, Goate, Alison M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - blood Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - cerebrospinal fluid Amyloid beta-Peptides - genetics Biology and Life Sciences Blood Proteins - genetics Cerebrospinal fluid Chemokine CCL2 - genetics Chemokine CCL4 - genetics Development and progression Female Genes Genetic aspects Genetic polymorphisms Genome-Wide Association Study Humans Male Matrix Metalloproteinase 3 - genetics Medical research Medicine and Health Sciences Nerve Growth Factor - genetics Physiological aspects Polymorphism, Single Nucleotide Receptors, Interleukin-6 - genetics Receptors, Lipoprotein - genetics Renin - genetics Studies tau Proteins - cerebrospinal fluid tau Proteins - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!