Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling

Genome maintenance in germ cells is critical for fertility and the stable propagation of species. While mechanisms of meiotic DNA repair and chromosome behavior are well-characterized, the same is not true for primordial germ cells (PGCs), which arise and propagate during very early stages of mammal...

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Veröffentlicht in:	PLoS genetics 2014-07, Vol.10 (7), p.e1004471-e1004471
Hauptverfasser:	Luo, Yunhai, Hartford, Suzanne A, Zeng, Ruizhu, Southard, Teresa L, Shima, Naoko, Schimenti, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Ataxia Telangiectasia Mutated Proteins - biosynthesis Ataxia Telangiectasia Mutated Proteins - genetics Biology and Life Sciences Care and treatment Cell adhesion & migration Cell division Defects Deoxyribonucleic acid Diagnosis DNA DNA damage DNA repair DNA Repair - genetics DNA Replication - genetics Embryos Fanconi Anemia - genetics Fanconi Anemia - pathology Fanconi's anemia Females Genetic aspects Genomes Genomic Instability Germ cells Germ Cells - metabolism Germ Cells - pathology Growth models Humans Hypogonadism - genetics Hypogonadism - pathology Mice Mutation Proteins rho GTP-Binding Proteins - biosynthesis rho GTP-Binding Proteins - genetics Rodents Signal Transduction - genetics Studies Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics
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