Essential genetic interactors of SIR2 required for spatial sequestration and asymmetrical inheritance of protein aggregates

Sir2 is a central regulator of yeast aging and its deficiency increases daughter cell inheritance of stress- and aging-induced misfolded proteins deposited in aggregates and inclusion bodies. Here, by quantifying traits predicted to affect aggregate inheritance in a passive manner, we found that a p...

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Veröffentlicht in:	PLoS genetics 2014-07, Vol.10 (7), p.e1004539-e1004539
Hauptverfasser:	Song, Jia, Yang, Qian, Yang, Junsheng, Larsson, Lisa, Hao, Xinxin, Zhu, Xuefeng, Malmgren-Hill, Sandra, Cvijovic, Marija, Fernandez-Rodriguez, Julia, Grantham, Julie, Gustafsson, Claes M, Liu, Beidong, Nyström, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - genetics Actin Cytoskeleton - metabolism Actins - metabolism Aggregates Aging Analysis Asymmetry Biology and Life Sciences BUDDING YEAST Cables Calmodulin Calmodulin - metabolism Cell division Cell Division - genetics Cell Polarity - genetics Colleges & universities Cytoskeleton DAMAGED PROTEINS Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism ENDOPLASMIC-RETICULUM Experiments Gene Expression Regulation Gene Regulatory Networks Genetics & Heredity Heat shock proteins Heat-Shock Proteins - metabolism INTERACTION NETWORK LIFE-SPAN Medical Genetics and Genomics Medicinsk genetik och genomik Microbiology in the Medical Area Mikrobiologi inom det medicinska området MISFOLDED PROTEINS Muscle proteins Myosin Myosin Heavy Chains - metabolism Myosin Type V - metabolism Physiological aspects Protein Aggregates - genetics Proteins QUALITY-CONTROL Saccharomyces cerevisiae Proteins - metabolism SACCHAROMYCES-CEREVISIAE Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sirtuin 2 - genetics Sirtuin 2 - metabolism STRUCTURED ILLUMINATION MICROSCOPY YEAST ACTIN CYTOSKELETON
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