A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis

The formation of mature cells by blood stem cells is very well understood at the cellular level and we know many of the key transcription factors that control fate decisions. However, many upstream signalling and downstream effector processes are only partially understood. Genome wide association st...

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Veröffentlicht in:	PLoS genetics 2014-07, Vol.10 (7), p.e1004450-e1004450
Hauptverfasser:	Bielczyk-Maczyńska, Ewa, Serbanovic-Canic, Jovana, Ferreira, Lauren, Soranzo, Nicole, Stemple, Derek L, Ouwehand, Willem H, Cvejic, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Blood platelets Cell Differentiation - genetics Chromosomes Deaths Embryos Experiments Gene Expression Profiling Gene loci Genetic aspects Genetic Loci Genetic research Genome-wide association studies Genome-Wide Association Study Genomes Genomics Grants Hematopoiesis - genetics Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Medical research Medicine and Health Sciences Physiological aspects Polymorphism, Single Nucleotide Rodents Zebra fish Zebrafish - blood
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