Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells

Epidermal growth factor receptor variant III (EGFRvIII) has been associated with glioma stemness, but the direct molecular mechanism linking the two is largely unknown. Here, we show that EGFRvIII induces the expression and secretion of pigment epithelium-derived factor (PEDF) via activation of sign...

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Veröffentlicht in:	PLoS biology 2015-05, Vol.13 (5), p.e1002152-e1002152
Hauptverfasser:	Yin, Jinlong, Park, Gunwoo, Kim, Tae Hoon, Hong, Jun Hee, Kim, Youn-Jae, Jin, Xiong, Kang, Sangjo, Jung, Ji-Eun, Kim, Jeong-Yub, Yun, Hyeongsun, Lee, Jeong Eun, Kim, Minkyung, Chung, Junho, Kim, Hyunggee, Nakano, Ichiro, Gwak, Ho-Shin, Yoo, Heon, Yoo, Byong Chul, Kim, Jong Heon, Hur, Eun-Mi, Lee, Jeongwu, Lee, Seung-Hoon, Park, Myung-Jin, Park, Jong Bae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autocrine Communication Biomedical research Brain cancer Brain research Cancer Chemotherapy Development and progression Disease Progression Epidermal growth factor ErbB Receptors - metabolism Eye Proteins - metabolism Female Gene expression Genetic aspects Glioma - etiology Glioma - metabolism Glioma - mortality Gliomas Health aspects HEK293 Cells Humans Identification and classification Kinases Mass spectrometry Medical prognosis Mice, Inbred BALB C Mice, Nude Neoplasms, Experimental - metabolism Neoplastic Stem Cells - metabolism Nerve Growth Factors - metabolism NMR Nuclear magnetic resonance Proteins Proteomics R&D Radiation therapy Receptors, Notch - metabolism Research & development Rodents Scientific imaging Serpins - metabolism SOXB1 Transcription Factors - metabolism STAT3 Transcription Factor - metabolism Stem cells Tumors
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